美国BSG（Biotech Support Group''LLC）公司是一家公司是一家全球知名的蛋白质组和基因组样本预处理的公司，是这个领域公认的领导者，该公司将其发明的专利表面化学技术应用生物学领域，比其他方法如亲合技术，苯酚法有绝对的优势。由于技术上的领先，使得BSG公司的产品广泛被美国国家基因组研究所，斯坦福大学等重要机构使用。（http://www.biotechsupportgroup.com/）

Nature Article Cites HemogloBind™ and NRicher™ for Macromolecular Complex Annotation

MONMOUTH JUNCTION, NJ, February 9, 2016 -- Biotech Support Group reports on a recent research article published in Nature, describing the simplicity and efficiency of their proteomic enrichment technology to observe and annotate soluble multiprotein complexes common to metazoa.


The citation is:

C Wan, B Borgeson, S Phanse, F Tu, K Drew, G Clark, et al. Panorama of ancient metazoan macromolecular complexes. Nature 525, 339–344 (17 September 2015).

doi:10.1038/nature14877


In brief, the article’s authors aimed at elucidating the components of multiprotein complexes on a proteome-wide scale. The authors identify protein complexes from nine species in parallel, based on biochemical fractionation of native soluble macromolecular complexes followed by tandem mass spectrometry to identify components. The article states “…clarified heart and liver homogenates were frozen, and subsequently pooled, depleted of hemoglobin using HemogloBind™ according to manufacturer’s instructions…prior to sucrose gradient fractionation. A second Biotech Support Group product, formerly called SeraFILE PROspector and now trademarked as NRicher™ 6, was used for sub-proteome enrichment. The article states “Affinity bead based sample pre-separations were performed forC. elegans lysates as per manufacturer’s instructions…fractions (SeraFILE bead eluates) were subjected to ion exchange fractionation…”. The authors conclude that many complexes are conserved across species, and by correlating the results with genome sequence information, are able to predict more than one million interactions in 122 eukaryotes.

“I am very pleased that two of our products were able to contribute to this rigorous examination of protein complexes. When our products were used as a pretreatment step in the overall workflow, about twice the number of observations and annotations became possible. This further validates that the sub-proteome bias characteristics of NRicher™ 6 can simplify complex proteomes into less complex sub-proteomes with efficiencies suitable for deep functional proteome characterization. Furthermore, this study demonstrated the importance of a key feature implicit to all of our products; that is the maintenance of functional and structural integrity after separations. Without that particular feature, these additional observations would not have been possible.” states Swapan Roy, Ph.D., President and Founder of Biotech Support Group.

苏州蚂蚁淘生物科技有限公司成立于2017年，致力于将全球领先的创新产品和前沿技术带入中国，帮助国内科研工作者在第一时间接触世界范围内的技术革命，并分享研发工具的进步带来的技术红利。依托于集团公司深厚的资源和超过400家的国内优质客户群体，生命科学领域的一站式供应链体系，以及高风险生物危险材料进出口平台的优势，蚂蚁淘生物严格筛选国际创新且经过同行验证过的产品和技术，引入中国市场，开发、孵育和推广。公司的未来将立足于实验室大数据整合和电子商务，结合严格的品牌筛选、创新的营销模式、专注的应用支持和坚实服务，帮助实现生命科学产业链的简单和高效。