ActionsCite Favorites Display options Display options Format 1 Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy. 1 Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy. Chemokines coordinate leukocyte recruitment during inflammatory and immune responses through the interaction with a distinct subfamily of G protein-coupled receptors. The magnitude of the cellular response elicited by chemokines is dictated by the level of receptor expression at the plasma membrane, which is the balance of finely tuned endocytic and recycling pathways. Recent data have revealed that receptor trafficking properties can drive chemokine receptors to lysosomal degradation or recycling pathways, producing opposite effects on the strength of the intracellular signaling cascade. This review will cover recent advances on the molecular mechanisms underlying chemokine receptor internalization, recycling and degradation pathways, with particular attention to structural motifs present in receptor intracellular domains and their interacting adaptor proteins that modulate receptor trafficking and dictate proper biological response. Neel NF, et al. Cytokine Growth Factor Rev. 2005 Dec;16(6):637-58. doi: 10.1016/j.cytogfr.2005.05.008. Epub 2005 Jul 5. Cytokine Growth Factor Rev. 2005. PMID: 15998596 Free PMC article. Review. Mukherjee S, et al. Circ Res. 2006 Mar 31;98(6):743-56. doi: 10.1161/01.RES.0000214545.99387.e3. Circ Res. 2006. PMID: 16574915 Marchese A. Curr Opin Cell Biol. 2014 Apr;27:72-7. doi: 10.1016/j.ceb.2013.11.011. Epub 2013 Dec 14. Curr Opin Cell Biol. 2014. PMID: 24680433 Free PMC article. Review. Wolfe BL, et al. Traffic. 2007 May;8(5):462-70. doi: 10.1111/j.1600-0854.2007.00551.x. Epub 2007 Mar 21. Traffic. 2007. PMID: 17376169 Wang D, et al. Front Genet. 2021 May 11;12:650213. doi: 10.3389/fgene.2021.650213. eCollection 2021. Front Genet. 2021. PMID: 34046056 Free PMC article. Metzemaekers M, Cambier S, Blanter M, Vandooren J, de Carvalho AC, Malengier-Devlies B, Vanderbeke L, Jacobs C, Coenen S, Martens E, Pörtner N, Vanbrabant L, Van Mol P, Van Herck Y, Van Aerde N, Hermans G, Gunst J, Borin A, Toledo N Pereira B, Dos Sp Gomes AB, Primon Muraro S, Fabiano de Souza G, S Farias A, Proenca-Modena JL, R Vinolo MA; CONTAGIOUS Consortium, Marques PE, Wouters C, Wauters E, Struyf S, Matthys P, Opdenakker G, Marques RE, Wauters J, Gouwy M, Proost P. Metzemaekers M, et al. Clin Transl Immunology. 2021 Apr 29;10(4):e1271. doi: 10.1002/cti2.1271. eCollection 2021. Clin Transl Immunology. 2021. PMID: 33968405 Free PMC article. Fowell DJ, et al. Nat Rev Immunol. 2021 Feb 24. doi: 10.1038/s41577-021-00507-0. Online ahead of print. Nat Rev Immunol. 2021. PMID: 33627851 Toth K, Nagi K, Slosky LM, Rochelle L, Ray C, Kaur S, Shenoy SK, Caron MG, Barak LS. Toth K, et al. ACS Pharmacol Transl Sci. 2019 Jun 3;2(4):230-246. doi: 10.1021/acsptsci.9b00018. eCollection 2019 Aug 9. ACS Pharmacol Transl Sci. 2019. PMID: 32259059 Free PMC article. Metzemaekers M, et al. Cell Mol Immunol. 2020 May;17(5):433-450. doi: 10.1038/s41423-020-0412-0. Epub 2020 Apr 1. Cell Mol Immunol. 2020. PMID: 32238918 Free PMC article. Review.