Anti Ga13 Rabbit Polyclonal Antibody-蚂蚁淘商城

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Anti Ga13 Rabbit Polyclonal Antibody

2024-04-30

货号：	21005
抗体名：	抗Ga13 兔多克隆抗体
抗体英文名：	Anti Ga13 Rabbit Polyclonal Antibody
靶点：	Ga13
应用范围：	WB,IF
宿主：	兔
供应商：	NewEastbio
数量：	30
级别：	实验级
目录编号：	21005
抗原来源：	兔
保质期：	1年
适应物种：	脊椎动物
标记物：	无
克隆性：	是
保存条件：	-20℃
形态：	液体
免疫原：	Recombinant full length Gα13 protein
规格：	100ul

Gα13 [21005][100 µL]

Catalog Number: 21005

Gene Symbol: Ga13

Description: Anti-Gα₁₃ Rabbit Polyclonal Antibody

Background: Heterotrimeric G proteins are essential cellular signal transducers. Gα₁₃is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα₁₃ are being explored.

Immunogen: Recombinant full length Gα₁₃ protein

Applications: ELISA, WB, IHC

Recommended Dilutions: ELISA 1:100-1:5000WB 1:100-1:2000IHC 1:50-1:100

Concentration: 1 mg/ml

Host: Rabbit

Format: Liquid

Clonality: Polyclonal

Isotype:

Purity: Purified from serum

Storage buffer:

Preservative: no

Constituents: PBS (without Mg²⁺ and Ca²⁺), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Gα₁₃ polyclonal antibody recognizes Gα₁₃ of vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Western blot:

Western blot analysis of Gα₁₃ proteins. MEF whole-cell lysates were used for western blot with anti-Gα₁₃polyclonal antibody (Cat. # 21005).

Immunofluorescence:

Immunofluorescence of mouse embryonic fibroblast (MEF) cells. Wild-type MEF cells (top panel) and Gα₁₃double knock-out cells (Gα₁₃ -/-, bottom panel) were fixed and stained with anti-Gα₁₃ polyclonal antibody (Cat. # 21005). Arrows indicate the dorsal ruffle strcture of one cell.

Publications:

1. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem. 2011 Sep 2;286(35):31055-61

2. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2 Br J Pharmacol. 2011 Feb;162(3):733-48

3. Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation Carcinogenesis (2010)

4. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency J Biol Chem. 2009 Oct 2;284(40):27409-15

温馨提示：不可用于临床治疗。

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