Human Her2 / ErbB2 Protein, Strep Tag-蚂蚁淘商城

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Human Her2 / ErbB2 Protein, Strep Tag

2025-06-13

货号：	HE2-H5287-50ug
供应商：	ACROBiosystems
数量：	In Stock
英文名：	Human Her2 / ErbB2 Protein, Strep Tag
规格：	50ug

内毒素:Less than 1.0 EU per μg by the LAL method. 纯度:>95% as determined by SDS-PAGE. 活性:Measured by its binding ability in a functional ELISA.Immobilized Human Her2, Strep Tag (Cat# HE2-H5287) at 2 μg/mL (100 μl/well) can bind trastuzumab with a linear range of 0.1-2 ng/mL. 产品背景:Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer,communication at the neuromuscular junction andregulation of cell growth and differentiation. 产品描述:Human Her2, Strep Tag is fused with twin strep tag at the C-terminus, and has a calculated MW of 72.4 kDa. The predicted N-terminus is Thr 23. The reducing (R) protein migrates as 110-115 kDa in SDS-PAGE due to glycosylation. 温馨提示：不可用于临床治疗。

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