AICARisacell-permeableactivatorofAMP-activatedproteinkinase(AMPK),ametabolicsensorinvolvedinbothcellularandwholebodyenergyhomeostasis.Invivo,pharmacologicactivationofAMPKwithAICARmimicsexerciseandtriggersinsulin-independentglucoseuptakebyskeletalmuscle.AICARisabletoactivatethemolecularcircuitryofpluripotencyinmESCandtoinducetheexpressionofseveralkeyregulatorsofpluripotencyinsomaticcells.
AdditionalInformation
| Synonyms | AICA-Riboside;NSC105823,Acadesine |
|---|---|
| Product# | A-1716 |
| CAS# | 2627-69-2 |
| ChemicalName | 5-Aminoimidazole-4-carboxamide1-β-D-ribofuranoside |
| Formula | C9H14N4O5 |
| MW | 258.23 |
| Appearance | TanPowder |
| Purity | ≥98%byHPLC |
| Solubility | H₂O |
| StorageTemp | -20°C |

