
MolecularFormula: | C24H25ClFN5O3 |
MolecularWeight: | 589.71g/mol |
CASNumber: | 220127-57-1 |
Appearance: | Whitetoslightlyyellowpowder |
Solubility: | SolubleinDMSOandwater.Sparinglysolubleinmethanol |
Purity: | ≥99% |
Storage: | -20ºC |
MaterialSafetyDataSheet
Date:Oct21,2015
1.PRODUCTANDCOMPANYIDENTIFICATION
1.1Productidentifier
Productname:ImatinibMesylate
CatalogNo:1100175002,1100170013,1100170023,1100170053,1100170103
1.2Relevantidentifiedusesofthesubstanceormixtureandusesadvisedagainst
Forresearchuseonly.
1.3Detailsofthesupplierofthesafetydatasheet
Company:EtonBioscienceInc
TollFree:1-800-758-1630
Tel:1-800-758-1630
Fax:1-800-507-2912
1.4Emergencytelephonenumber
1-800-758-1630
2.HAZARDSIDENTIFICATION
2.1Classificationofthesubstanceormixture
Acutetoxicity:oral,Category4
2.2GHSLabelelements,includingprecautionarystatements
Pictogram
SignalWord | Warning |
HazardStatement | |
H302 | Harmfulifswallowed |
Precautionarystatement | |
P264 | Washskinthoroughlyafterhandling |
P302+P312 | IFSWALLOED:CallaPOISONCENTERordoctor/physicianifyoufeelunwell. |
P330 | Rinsemouth |
P501 | Disposeofcontents/containertoanapprovedwastedisposalplant |
2.3Otherhazards
None
3.COMPOSITION/INFORMATIONONINGREDIENTS
3.1Substances
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamidemethanesulfonate
MolecularFormula:C₂₉H₃₁N₇O.CH₄SO₃
MolecularWeight:589.71g/mol
CASNo:220127-57-1
4.FIRSTAIDMEASURES
4.1Descriptionoffirstaidmeasures
Eyecontact
Checkforandremovecontactlensesandflushwithcopiousamountsofwater;assureadequateflushingbyseparatingtheeyelidswithfingers;callaphysician
SkinContact
flushwithcopiousamountsofwater;removecontaminatedclothingandshoes;callaphysician
Inhalation
Ifinhaled,removetofreshair;ifbreathingisdifficult,giveoxygen;ifbreathingstops,giveartificialrespiration
Ingestion
ifswallowed,washoutmouthwithcopiousamountsofwater;callaphysician
4.2Mostimportantsymptomsandeffects,bothacuteanddelayed
Noinformationavailable
4.3Indicationofanyimmediatemedicalattentionandspecialtreatmentneeded.
Noinformationavailable
5.FIREFIGHTINGMEASURES
5.1Extinguishingmedia
Suitableextinguishingmedia
waterspray,carbondioxide,drychemicalpowderorfoam
5.2Specialhazardsarisingfromthesubstanceormixture
Noinformationavailable
5.3Adviceforfirefighters
Wearself-containedbreathingapparatusandprotectiveclothingtopreventcontactwithskinandeyes.
6.ACCIDENTALRELEASEMEASURES
6.1Personalprecautions,protectiveequipmentandemergencyprocedures
Usefullpersonalprotectiveequipment.Evacuatepersonneltosafeareas.
6.2Environmentalprecautions
Preventfurtherleakageorspillage.Preventproductfromenteringdrain.
6.3Methodsandmaterialforcontainmentandcleaningup
Absorbsolutionswithfinely-powderedliquid-bindingmaterial(diatomite,universalbinders);decontaminatesurfacesandequipmentbyscrubbingwithalcohol;disposeofcontaminatedmaterialaccordingtoSection13
7.HANDLINGANDSTORAGE
7.1Precautionsforsafehandling
Avoidskin/eyecontact.Useprotectiveequipmentasneeded.Washcontaminatedclothingbeforereuse.
7.2Conditionsforsafestorage,includinganyincompatibilities
Keepcontainertightlyclosedinacool,well-ventedplace.Storeat-20˚C.
7.3Specificenduse(s)
Nodataavailable.
8.EXPOSURECONTROLS/PERSONALINFORMATION
8.1ControlParameters
Thisproductcontainsnohazardousmaterialswithoccupationalexposurelimits.
8.2Exposurecontrols
Engineeringcontrols
Provideshowerandeyewashstation
Personalprotectiveequipment
EyeProtection | Wearsafetygoggles |
SkinProtection | Wearprotectiveclothing |
HandProtection | Wearprotectivegloves |
Respiratoryprotection | WearNIOSH/MSHAapprovedrespirators |
9.PHYSICALANDCHEMICALPROPERTIES
9.1Informationonbasicphysicalandchemicalproperties
Appearance | Solid |
pH | Nodataavailable |
Meltingpoint | Nodataavailable |
Freezingpoint | Nodataavailable |
Boilingpoint | Nodataavailable |
Density | Nodataavailable |
Watersolubility | Verypoorlysoluble |
9.2Othersafetyinformation
Nodataavailable.
10.STABILITYANDREACTIVITY
10.1Reactivity
Nodataavailable
10.2Chemicalstability
Stableunderrecommendedstorageconditions.
10.3Possibilityofhazardousreactions
Nodataavailable.
10.4Conditionstoavoid
Protectfromlightandheat
10.5IncompatIBLematerials
strongoxidizingagents
10.6Hazardousdecompositionproducts
Thermaldecompositionmayproducetoxicgasessuchascarbonmonoxide,carbondioxide,andnitrogenoxides
11.TOXICOLOGICALINFORMATION
11.1Informationontoxicologicaleffects
Toxicologicaleffectsonthisproducthavenotbeenthoroughlystudied.
12.ECOLOGICALINFORMATION
12.1Toxicity
Avoidreleaseintoenvironment
12.2Persistenceanddegradability
Nodataavailable
12.3.Bioaccumulativepotential
Nodataavailable
12.4Mobilityinsoil
Nodataavailable
12.5ResultsofPBTandvPvBassessment
Nodataavailable
12.6Otheradverseeffects
Nodataavailable
13.DISPOSALINFORMATION
13.1Wastetreatmentmethods
Disposeinaccordancewithlocal,state,andfederalregulations.
14.TRANSPORTINFORMATION
DOT:
Propershippingname:none
Non-Hazardousfortransport:thissubstanceisconsideredtobenon-hazardousfortransport
IATA:
Propershippingname:none
Non-Hazardousfortransport:thissubstanceisconsideredtobenon-hazardousfortransport
IMDG:
Propershippingname:none
Non-Hazardousfortransport:thissubstanceisconsideredtobenon-hazardousfortransport
15.REGULATORYINFORMATION
EURiskandSafetyphrases:
R22:Harmfulifswallowed
S22:Donotbreathedust
S24/25:Avoidcontactwithskinandeyes
S26:Incaseofcontactwitheyes,rinseimmediatelywithplentyofwaterandseekmedicaladvice
S28:aftercontactwithskin,washimmediatelywithplentyofwater
S36/37/39:Wearsuitableprotectiveclothing,glovesandeye/faceprotection
16.OTHERINFORMATION
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适应症下会标注“本品适用于敏感菌所致......”字样;
药理作用下会标注“本品属......类抗菌素”字样。
2.β-内酰胺类青霉素(阿莫西林、氨苄西林、羧苄西林) 头孢菌素、碳青霉烯类、头霉素、单内酰环类、β-内酰酶抑制剂、甲氧青霉素类
3.大环内酯类 红霉素、白霉素(吉他霉素)、罗红霉素、阿奇霉素、克拉霉素、乙酰螺旋霉素、麦迪霉素、交沙霉素等
4 酰胺醇类:包括氯霉素、甲砜霉素等
5 四环素类:包括四环素、土霉素(强力霉素)、金霉素等
6 林可酰胺类 克林霉素、林可霉素
7.糖肽类抗生素: 比如万古霉素、替考拉宁
8 抗真菌抗生素:如灰黄霉素、两性霉素B
9 抗肿瘤抗生素:如丝裂霉素、放线菌素D、博莱霉素、阿霉素等
10 具有免疫抑制作用的抗生素如环孢霉素
11 多磷类抗生素:如磷霉素

