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CaMKII,amemberofthecalcium/calmodulin-activatedproteinkinasfamily,functionsinneuralsynapaticstimulationandT-cellreceptorsignaling.CaMKIIisexpressedinmanytissues,butitisspecificallyfoundintheneuronsoftheforebrain,anditsmRNAisfoundwithinthedendritesandthesomaoftheneuron.
CaMKIIinneuronsconsistsoftwosubunitsof52(alphagenes)and60kDa(betagenes).CaMKIIhascatalyticandregulatorydomainsaswellasanATP-bindingdomainandaconsensusphosphorylationsite.
Bindingofcalcium/calmodulintoitsregulatorydomainreleasesitsauto-inhibitoryeffectandactivatesthekinase.Thiskinaseactivationresultsinautophosphorylationatthreonine286.
AutophosphorylationconfersenhancedaffinityofCaMKIIforNMDAreceptorsinpostsynapticdensities.
Thisantibodyrecognizesthephosphorylatedandnon-phosphorylatedformsofmouse,rat,andbovineCaMKII.
Immunoblotting:useat0.1-1ug/ml.Abandof~50-60kDaisdetected.
Immunohistochemistry:useat10ug/ml.
RIA:useat3-5ug/ml.
Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Ratbraintissueextract.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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productivitybyusingmannoseascarbonsource:Metabolicanalysisand
scale-upsimulation》
2.《Adetailedmetabolic?uxanalysisofanunderdeterminednetworkofCHOcells》
1-s2.0-S0009250911001771-main.pdf(328.24k)
1-s2.0-S016816561001878X-main.pdf(521.01k)
酶的作用是催化剂,促进或抑制反应的进行.加热主要是通过升高温度加快反应速率,无机催化剂和酶的原理相同,都是通过降低反应的活化能加快反应速率
解析:1.细胞质基质(也叫胞质溶胶)是指除细胞器外细胞质的其余部分。细胞质基质是活细胞进行新陈代谢的主要场所。
2.细胞新陈代谢的次要场所是:细胞核、线粒体基质、叶绿体基质等基质。
不破坏细胞结构,同步动态侦测细胞有氧呼吸,糖酵解OCR/ECA(总或乳酸ECA);
i.过氧敏感荧光素(或pH敏感荧光素),Ex340-380/535/Em630-680nm,实时测量线粒体/胞内/胞外重要代谢指标,荧光素为非结构性结合可逆转改变;
ii.可同时或单个测量OCR/ECA或其他参数,不会做成浪费,可采用时间分辨荧光技术可加强系统信噪比
iii.通过两个加药口,可对检测细胞加入适当抑制剂/刺激实时监测细胞对不同毒素作用
A.衰老的细胞新陈代谢速率加快
B.在衰老的细胞内有些酶的活性降低
C.衰老的细胞呼吸速率减慢
D.细胞膜通透性改变,使物质运输功能降低

