编号：XY-1255R
Theproteinencodedbythisgeneisamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivitiesandareinvolvedinavarietyofbiologicalprocessesincludingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.Thisgenewasidentifiedbyitssimilaritywithmousefgf3/int-2,aproto-oncogeneactivatedinvirallyinducedmammarytumorsinthemouse.Frequentamplificationofthisgenehasbeenfoundinhumantumors,whichmaybeimportantforneoplastictransformationandtumorprogression.Studiesofthesimilargenesinmouseandchickensuggestedtheroleininnerearformation.
Function:Fibroblastgrowthfactors(FGFs)canstimulatetheproliferationofmesenchymal,epithelialandneuroectodermalcells.FGF3belongstotheheparinbindinggrowthfactorsfamily.MembersofthefamilyincludeAcidicFGF(alsoknownasaFGForFGF1),basicFGF(bFGForFGF2),FGF3(alsoknownasInt2)andFGF4(alsoknownashstorKaposiFGF).FGF4wasfirstrevealedtobeanoncoproteininKaposi'ssarcomacells.OtherfamilymembersincludeFGF5,FGF6,FGF7(keratinocytegrowthfactor,KGF),FGF8(AIGF),FGF9(GAF)andFGF10.FGF3isactivatedbyproviralinsertionofmousemammarytumorvirus(MMTV).FGF3isresponsibleformostofbreastmalignancies.
Subunit:InteractswithFGFR1andFGFR2.Affinitybetweenfibroblastgrowthfactors(FGFs)andtheirreceptorsisincreasedbyheparansulfateglycosaminoglycansthatfunctionascoreceptors(Bysimilarity).
SubcellularLocation:Secreted.
Post-translationalmodifications:Glycosylated.
Similarity:Belongstotheheparin-bindinggrowthfactorsfamily.
Databaselinks:UniProtKB/Swiss-Prot:P05524.3
纤维母细胞生长因子3是FGF家族的成员。FGF家族参与一系列的生理功能：胚胎发育、细胞生长、器官形成、组织修复、肿瘤生长、侵袭等。FGF3/FGF4在很多恶性肿瘤中呈高表达，被视为原癌基因之一。
