

BioVortexer
The BioVortexer™ is a battery-powered motor drive designed to rotate stirring rods or plastic pestles in 1.5 ml microtubes. Rotating at thousands of revolutions per minute, it makes short work of dispersing centrifugal pellets or grinding small tissue samples.
Cat. No. 1083MC, BioVortexer Stirring Kit. Includes motor, batteries and 100 - 1/8"X3" stirring rods.
Cat. No. 1083, BioVortexer, motor only. Batteries included.
Cat. No. 183, Additional BioVortexer polypropylene stirring rods, 1/8"X3" (500 count).
Cat. No. 1017MC, BioVortexer Grinding Kit. Includes motor, batteries, 100 SpiralPestles™ with matching 1.5 ml microvials and sample of SpiralPestle™ Grinding Beads.
Cat. No. 1017, Additional SpiralPestles™ with matching 1.5 ml microvials (100 count) and sample of SpiralPestle™ Grinding Beads.
Our Price : $0.00
The BioVortexer has two distinct applications...
- A practical alternative to a conventional vortex mixer for mixing and dispersing samples. Combined with Disposable Polypropylene Stirring Rods (1/8 X 3")*, it rapidly re-suspends precipitates such as pellets of protein or DNA. The working range is 10-500 mg of powdered or homogenized solids in a media volume of 0.5 to 10 ml. "Take the BioVortexer to the sample instead of the sample to the vortex mixer".
- A low cost device to rapidly homogenizing small samples of soft tissue for extraction of proteins and nucleic acids. The BioVortexer rotates Disposable Polypropylene SpiralPestles™ at ~9000 rpm in 0.6 or 1.5 ml conical microtubes containing sample, extraction media and a small quantity of glass grinding beads. Complete cell lysis of soft tissue samples is achieved in seconds. See SpiralPestle for more information on this new method.
- Rotates 3" Stirring Rods or Pestles in small tubes or microvials for rapid, efficient mixing or grinding of pellets or soft tissue
- Roration speed about.9000 rpm
- Lightweight
- Cordless: Uses two standard AA batteries
- Low cost
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如果女方的该基因为双显,则后代不会换此病(基因突变除外,所有基因都可能突变,但概率何其小);如果女方为单显,则男孩有一半的概率致病,女孩不会致病;如果女方也为隐性,则男孩致病,那就要个女孩吧。
结论,能不能生育去医院做精液检查就清楚了,如果可育,再让女方做个DNA鉴定以决定生儿育女。
protease
水解蛋白质肽键的一类酶的总称。按其水解多肽的方式,可以将其分为内肽酶和外肽酶两类。内肽酶将蛋白质分子内部切断,形成分子量较小的月示和胨。外肽酶从蛋白质分子的游离氨基或羧基的末端逐个将肽键水解,而游离出氨基酸,前者为氨基肽酶后者为羧基肽酶。按其活性中心和最适pH值,又可将蛋白酶分为丝氨酸蛋白酶、巯基蛋白酶、金属蛋白酶和酸性蛋白酶。按其反应的最适pH值,分为酸性蛋白酶、中性蛋白酶和碱性蛋白酶。工业生产上应用的蛋白酶,主要是内肽酶。
蛋白激酶
protein kinase
又称蛋白质磷酸化酶(protein phosphakinase)。一类催化蛋白质磷酸化反应的酶。
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Exercisedampensaromataseinhibitor–relatedjointpain
http://www.internalmedicinenews.com/specialty-focus/oncology-hematology/single-article-page/exercise-dampens-aromatase-inhibitor-related-joint-pain/33383ff19a0cd42399a7cf8590708ebf.html
SANANTONIO–Adoptingastandardexerciseprogramresultedinaclinicallymeaningful30%reductioninaromataseinhibitor-associatedjointpaininbreastcancerpatientswhoparticipatedinayear-longrandomizedtrial.
TheexerciseprescriptionutilizedintheHOPE(HormonesandPhysicalExercise)trialwaswhat’srecommendedinnationalguidelinesbothforcancersurvivorsandhealthyadults:150minutesperweekofatleastmoderate-intensityaerobicactivity,suchasbriskwalking,alongwithtwostrength-trainingsessionsperweek,MelindaL.Irwin,Ph.D.,explainedattheSanAntonioBreastCancerSymposium.
TheHOPEstudiesenrolled121postmenopausalwomenwhohadstage1-3,hormonereceptor–positivebreastcancersandwerephysicallyinactiveandoverweightyetphysicallyabletoexercise.Atenrollment,theywereexperiencingmoderatearomataseinhibitor(AI)–associatedjointpain,definedasascoreof5-7onthe0-10BriefPainInventory(BPI),afterabout18monthsonthemedication.Roughlytwo-thirdsofparticipantshadnohistoryofjointpainpriortostartingAItherapy;therestreportedtheAIexacerbatedtheirpreexistingjointpain.Subjectswererandomizedtotheexerciseprogramortousualcare,whichincludedwritteninformationabouttheimportanceofexercise.
Theprimarystudyendpointwasthe12-monthchangeinBPIworstpainscore,whichdroppedbyanaverageof30%amongtheexercisegroup.Thistranslatedtoanimprovementinpainlevelfrommoderateatbaselinetomildatfollow-up.Inaddition,BPIscoresratingpainseverityandpaininterferenceimprovedbyabout20%.Incontrast,patientsintheusualcarecontrolgroupexperiencedaslightincreaseinBPIscoresinallthreedomainsovertime,addedDr.Irwin,co-leaderofthecancerpreventionandcontrolresearchprogramatYaleUniversityCancerCenter,NewHaven,Conn.
TheHOPEresultsreceivedanenthusiasticaudiencereception.Physicianswereparticularlyimpressedwiththe70%exerciseadherencerateoverthecourseofayear.Theyaskedhowtheycankeeptheirpreviouslysedentarypatients’commitmenttoregularexercisefromwaningafteraninitialburstofenthusiasm,assooftenhappens.
Dr.Irwinrepliedthatadherencetolifestylechangeisalwaysachallenge.Socialsupportisquitehelpful.TheexercisegroupinHOPEreceivedapaidgymmembershipandmetinsmallgroupswithapersonaltrainertwiceweekly.
"Thewomenreallybondedwitheachother.Andtherearenowagrowingnumberoffreeprogramsthroughoutthecountry,whichgivecancersurvivorsastartonanexerciseprogramwithafreegymmembershipforseveralmonths.Forexample,theLivestrongFoundationhaspartneredwiththeYMCAtoofferfreeexerciseprogramsforcancersurvivorsatlocalYs,"shesaid.
TheHOPEtrialwasfundedbytheNationalCancerInstitute.Dr.Irwinreportedhavingnofinancialconflictsofinterest.
Thisdegreeofimprovementinjointpainisgreaterthanreportedinstudiesofglucosamine,acupuncture,orvitaminDsupplementation,shenoted.
Theimprovementinpainscoresintheexercisegroupwasgreaterat12monthsthanat3or6,suggestingthatayear-longexerciseprogramisprobablynecessarytoseesustainedreductioninjointpain.
At12monthsoffollow-up,womenintheexercisegroupaveraged159minutesofphysicalactivityperweek,110minutesmorethancontrols.Compliancewiththesupervisedexerciseprogramwasnotablygood,withwomenattendinganaverageof70%ofthetwice-weeklysmall-groupstrength-trainingsessions.
InadditiontotheimprovementinAI-relatedarthralgias,theexercisegroupexperiencedancillarybenefits:amean6.5%improvementinpeakoxygenconsumption,orVO2max,comparedwithbaseline,alongwitha3%reductioninbodyweight.
HOPEwasthefirstrandomizedtrialtoexaminetheeffectsofexerciseonAIsideeffectsinbreastcancerpatients.TheimpetusforthestudywastherecognitionthatarthralgiasarethemostcommonreasonforpooradherencetoanddiscontinuationofAItherapy.Upto20%ofbreastcancerpatientsdiscontinuetheirAIwithinthefirstyear.Andbothearlydiscontinuationandpooradherencehavebeenshowntobepredictiveofincreasedmortalityrisk.
那糖酵解中依赖NAD的酶不是要在线粒体内反应?
1、纳豆激酶是在纳豆发酵过程中由纳豆枯草杆菌(Bacillus subtilisl natto)产生的一种丝氨酸蛋白酶(单链多肽酶),分子量为27728道尔顿。
2、纳豆激酶在温度超过80℃时迅速变性失活,但反复冻融对其影响不大。
3、纳豆激酶在PH值从7升至12时,10min内稳定;PH值低于5时,迅速变性失活。胃酸环境中的PH值只有1.2到2之间,纳豆激酶根本无法通过。
4、纳豆激酶与粘性物质混合后,在PH值2-3的酸性环境中,还能保持不超过7.5%的活性。
5、纳豆激酶是大分子的单链多肽酶,可被肠道消化液(糜蛋白酶、胰蛋白酶、小肠液等)分解成氨基酸片段或分子量更小的肽链。
纳豆一词源于日本,是日本发酵食品,源自中国的咸豆豉,但并非中国豆豉,而是由黄豆通过纳豆菌(枯草杆菌)发酵制成豆制品,具有黏性,气味较臭,味道较甜,不仅保有黄豆的营养价值、富含维生素K2、提高蛋白质的消化吸收率,更重要的是发酵过程产生了多种生理活性物质,具有溶解体内纤维蛋白及其他调节生理机能的保健作用。

