Overview:
STAT1β is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT1β transcription factor is specific for the IFN pathway and plays a central role in mediating many, if not all, IFN-dependent biological responses (1). Presence of STAT1β leads to an efficient antiviral response when cells were infected with virus suggesting that a STAT-dependent pathway is activated following virus infection by endogenously produced IFN. Virus-induced STAT protein translocation from the cytoplasmic compartment can be detected within 3 h of infection.
Gene Aliases:
ISGF-3; STAT91; DKFZp686B04100
Genbank Number:
NM_139266
References:
1.Improta, T. et al: Susceptibility to virus infection is determined by a Stat-mediated response to the autocrine effect of virus-induced type I interferon. Cytokine. 1997 Jun;9(6):383-93.
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所以一个细菌或病毒可以有很多的抗原。
若已进入细胞内。则先由巨噬细胞吞噬降解。并形成抗原-MHC复合体传送到表面。被辅助性T淋巴细胞识别和效应T淋巴细胞识别后。效应T淋巴细胞被激活。分解靶细胞。然后再由效应B细胞分泌的抗体进一步消灭病毒。
还有不清楚的么?
荚膜(capsule)是某些细菌在生长繁殖过程中分泌的一层黏液性物质,包围在细胞壁外,通常这种黏液层厚度小于0.2μm,成分是多糖或多肽,只有在营养丰富时或在动物体内,细菌才产生这种半抗原性质的黏液性物质。它具有保护菌体免受巨噬细胞等的捕捉和吞噬,因而具有抗吞噬抗消化、侵袭力强、与致病性关系密切等特点。像肺炎球菌、炭疽杆菌等都有这类荚膜。有些细菌的荚膜层较薄,小于0.2μm,称为微荚。
像链球菌的M蛋白、伤寒杆菌的Vi抗原、大肠杆菌的K抗原等都属于这类微荚膜。
请赐教!

