Alpha Synuclein Preformed Fibrils (Type 1)
The Alpha Synuclein Preformed Fibrils (Type 1) is For Research Use Only
Specificity: ~14.46 kDa
Species: Human
Expression System: E. coli
Buffer: PBS
Storage Temperature: -80ºC
Product manufactured in Canada by StressMarq.
Alternative Names
Active Human Recombinant Alpha Synuclein Preformed Fibrils (Type 1), Active Alpha synuclein PFFs, Active Alpha synuclein aggregates, Active Alpha synuclein protein aggregates, Active Alpha synuclein aggregates, Active Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson disease familial 1 Protein, Active Alpha synuclein protein seed
Assay Background
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals. Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus. Functionally, it has been shown to significantly interact with tubulin, and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory. SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin.
Related Products
Alpha Synuclein Preformed Fibrils (Type 2)
Alpha Synuclein Protein Monomer (Type 1)
Alpha Synuclein Protein Monomer (Type 2)
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颗粒型抗原,除了有细菌、红细胞、螺旋体等天然颗粒型抗原,还有吸附有可溶性抗原的非免疫相关颗粒.
颗粒性抗原光镜下可见，比如细菌性抗原、红细胞抗原等；而可溶性抗原在光镜下不可见，如组织浸出液、细菌毒素、蛋白质分子等。
它们不等同于完全抗原和不完全抗原。完全抗原具有免疫原性和抗原性，而不完全抗原只具有抗原性。完全抗原可以是颗粒性抗原，亦可是可溶性抗原，而不完全抗原一般只能是可溶性抗原，不会是颗粒性抗原。
荚膜是某些细菌在细胞壁外包围的一层粘液性物质，一般由糖和多肽组成，是细菌的一种特殊结构。
作用：
①抗吞噬作用：荚膜因其亲水性及其空间占位、屏障作用，可有效抵抗寄主吞噬细胞的吞噬作用。
②黏附作用：荚膜多糖可使细菌彼此间粘连，也可黏附于组织细胞或无生命物体表面，是引起感染的重要因素，具有荚膜的S-型肺炎链球菌毒力强，有助于肺炎链球菌侵染人体；废水生物处理中的细菌荚膜有生物吸附作用，将废水中的有机物、无机物及胶体吸附在细菌体表面上。
③抗有害物质的损伤作用：处于细菌细胞最外层，荚膜犹如盔甲可有效保护菌体免受或少受多种杀菌、抑菌物质的损伤，如溶菌酶、补体等。
④抗干燥作用：荚膜多糖为高度水合分子，含水量在95%以上，可帮助细菌抵抗干燥对生存的威胁。
⑤当缺乏营养时，荚膜可被利用作碳源和能源，有的荚膜还可作氮源。
所以一个细菌或病毒可以有很多的抗原。
