- Description
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Description
Details
Description:Mouse monoclonal antibody to human serum amyloid A (SAA)
Purification:Protein G affinity purified
Product Type:Primary antibody
Target Protein:Human SAA
Immunogen:Highly purified recombinant human SAA (MW: 12 kDa)
Fusion Myeloma:Sp2/0-Ag14
Specificity:This monoclonal antibody reacts with natural and recombinant human SAA.
Species Reacitvity: Human, others not tested
Cross-Reactivity: Does not show any cross-reaction with other human cytokines or growth factors tested such as IL-1β, IL-8, MCAF, TGF-β and EGF.
Host / Isotype: Mouse, IgG2b Kappa
Formulation:Lyophilized from a solution in 0.01M PBS, pH 7.2
Reconstitution:Double distilled water is recommended to reconstitute the antibody.
Storage: Store at -20oC
Research Area:Acute phase protein. Inflammatory reaction.
Background:
SAA is an acute phase protein and a sensitive inflammatory marker. Cytokines such as IL-1, IL-6 and TNF-alpha stimulates hepatocytes to produce and release SAA. In acute phase, SAA in blood can increase to more than 1,000 folds of normal level. Prolonged and repeated elevation of SAA results in abnormal deposition of amyloid proteins in organ or tissue in insoluble beta pleated form. Determination of SAA levels is important for assessment of renal allograft rejection, estimation of tissue damage caused by myocardial infarction and severe angina, and diagnosis of inflammation in cystic fibrosis patients and in patients infected with virus.
Application:
ELISA:React with human SAA.
Western Blot: The antibody, when used at concentration of 0.1-0.5 μg/mL will allow visualization of 100ng/lane of recombinant human SAA.
References:
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
Additional
Additional Information
| Product Specificity | mAb anti-Human SAA, 504 |
|---|---|
| Application | EIA, WB |
| Size | 0.1 mg |
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所以一个细菌或病毒可以有很多的抗原。
若已进入细胞内。则先由巨噬细胞吞噬降解。并形成抗原-MHC复合体传送到表面。被辅助性T淋巴细胞识别和效应T淋巴细胞识别后。效应T淋巴细胞被激活。分解靶细胞。然后再由效应B细胞分泌的抗体进一步消灭病毒。
还有不清楚的么？
荚膜（capsule）是某些细菌在生长繁殖过程中分泌的一层黏液性物质，包围在细胞壁外，通常这种黏液层厚度小于0.2μm，成分是多糖或多肽，只有在营养丰富时或在动物体内，细菌才产生这种半抗原性质的黏液性物质。它具有保护菌体免受巨噬细胞等的捕捉和吞噬，因而具有抗吞噬抗消化、侵袭力强、与致病性关系密切等特点。像肺炎球菌、炭疽杆菌等都有这类荚膜。有些细菌的荚膜层较薄，小于0.2μm，称为微荚。
像链球菌的M蛋白、伤寒杆菌的Vi抗原、大肠杆菌的K抗原等都属于这类微荚膜。
请赐教！
