
MolecularWeight: | 1202.63 |
Formula: | C62H111N11O12 |
Purity: | ≥98% |
CAS#: | 59865-13-3 |
Solubility: | DMSOupto100mM,EtOHupto50mM |
Storage: | Powder:4oC1year.DMSO:4oC3month;-20oC1year. |
BIOLOGicalActivity:CyclosporinAisaninhibitorofthemitochondrialpermeABIlitytransitionpore(MPTP).ItprotectsmousebonemarrowandhumancordbloodHSCsfromEPHOSSduringcollectioninair,resultinginincreasedrecoveryoftransplantableHSCs.Itwasusedasimmunosuppressantandcouldinhibitphosphataseactivityofcalcineurin(IC50~5nM).HowtoUse:Invitro:CyclosporinAwasusedat50µg/mlinthecollectionofcordbloodprocess.Invivo:n/aReference:
- 1.MantelCR,etal.EnhancingHematopoieticStemCellTransplantationEfficacybyMitigatingOxygenShock.(2015)Cell.161(7):1553-65.
- 2.YanP,etal.Cyclosporin-ApotentlyinduceshighlycardiogenicProgenitorsfromembryonicstemcells.(2009)BiochemBiophysResCommun.379(1):115-20.
- 3.FrumanDA,etal.CalcineurinphosphataseactivityinTlymphocytesisinhibitedbyFK506andcyclosporinA.(1992)ProcNatlAcadSciUSA.89(9):3686-90.


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我们产品注册的时候在安全性说明上标明了该仪器由专业人员操作,所以不考虑这条。但是药监局老师说应该考虑。请教各位,这个如果考虑的话,该怎么进行符合性证明?如果可以不考虑的话,请问有什么法规或文件支持?

