
Description | iCRT3isanantagoNISTofWnt/β-cateninsignalingwithanIC50of8.2nMintheWntresponsiveSTF16-lucreporterassays. | ||
---|---|---|---|
Targets |
| ||
Invitro | iCRT3isasmallmoleculeinhibitoroftheWntpathwaywhichbindstoβ-catenininterferingwithitsinteractionwithTCF.iCRT3significantlyreducestheLPS-inducedWnt/β-cateninactivityandalsoinhibitsTNF-αproductionandIκBdegradationinadose-dependentmanner.iCRT3doesnotinfluencethetranscriptionalactivityofFOP-Flashluciferasereporter,whichharborsmutationsintheDNAbindingsitesforTCF(β-catresponseelement),showingspecificityoftheresponse.ItinhibitscytokineproductioninLPS-stimulatedmacrophages[1][2]. | ||
Invivo | IntraperitonealadministrationofiCRT3toC57BL/6mice,subjectedtocecalligationandpuncture-inducedsepsis,decreasestheplasmalevelsofproinflammatorycytokinesandorganinjuryMarkersinadose-dependentmanner.ThehistologicalintegrityofthelungsisimprovedwithiCRT3treatment,alongwithreducedlungcollagendepositionandapoptosis.Inaddition,iCRT3treatmentalsodecreasestheexpressionofthecytokines,neutrophilchemoattractants,aswellastheMPOactivityinthelungsofsepticmice[2]. |
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>

