MolecularWeight: | 296.32 |
Formula: | C18H16O4 |
Purity: | ≥98% |
CAS#: | 97846-18-9 |
Solubility: | DMSOupto100mM |
ChemicalName: | 3-(4-hydroxyphenyl)-7-isopropoxy-4H-chromen-4-one |
Storage: | Powder:4oC1year.DMSO:4oC3month;-20oC1year. |
BIOLOGicalActivity:
Daidzein-2cisapotentsyntheticdaidzeinanalog,hasosteogenicinductionpotentialsonhumanMesenchymalStemCells(MSC).HumanbonemarrowderivedmesenchymalstemcellsfromthreedifferentdonorsweretreatedwithDaidzein-2candshowntoexhibitenhancedosteogenesiswhencomparedtodaidzeinorestrogentreatment.TheenhancedosteogenicinductionbyDaidzein-2cresultedinincreasedosterix(Sp7),alkalinephosphatase(ALP),osteopontin(OPN),andinsulin-likegrowthfactor1(IGF-1),whichareosteogenicfactorsthatregulatethematurationofosteogenicProgenitorcellsintomoredifferentiatedosteoblastcells.Itservesasausefulchemicaltooltofurthervalidateanddevelopnoveltreatmentsofosteoporosisviapromotingboneformation.
HowtoUse:
- Invitro:Daidzein-2cwasusedat1µMfinalconcentrationinvariousinvitroassays.
- Invivo:N/A
Reference:
- 1.AmyL,etal.Design,Synthesis,andOsteogenicActivityofDaidzeinAnalogsonHumanMesenchymalStemCells.(2014)ACSMed.Chem.Lett.,Inpress.
- Daidzein-2c_spec.pdf
- Daidzein-2c_MSDS.pdf
Productsareforresearchuseonly.Notforhumanuse.
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