- Droxidopa
- Serotonin HCl
- Epinephrine HCl
- Dynorphin (2-17), amide, porcine
- DL-Adrenaline
- Piracetam
| alpha-EndorphinNeurotransmitters |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MS (Mass Spectrometry)(Retest)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
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| Cas No. | 59004-96-5 | SDF | Download SDF |
| Synonyms | H2N-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH | ||
| Chemical Name | N/A | ||
| Canonical SMILES | CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)O)NC(=O)C1CCCN1C(=O)C(C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CCSC)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=C(C=C3)O)N | ||
| Formula | C77H120N18O26S | M.Wt | 1745.95 |
| Solubility | ≥174.5mg/mL in DMSO | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Endorphins are endogenous opioid peptides that function as neurotransmitters(1). They are produced by the pituitary gland and the hypothalamus in vertebrates during exercise, excitement, pain, consumption of spicy food, love and orgasm, and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being.The term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine(2), Beta-endorphin (β-Endorphin) is released into blood from the pituitary gland and into the spinal cord and brain from hypothalamic neurons. The β-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood–brain barrier, so the physiological importance of the β-endorphin that can be measured in the blood is far from clear. β-Endorphin is a cleavage product of pro-opiomelanocortin (POMC), which is also the precursor hormone for adrenocorticotrophic hormone (ACTH). The behavioural effects of β-endorphin are exerted by its actions in the brain and spinal cord, and it is presumed that the hypothalamic neurons are the major source of β-endorphin at these sites. In situations where the level of ACTH is increased (e.g., Cushing’s Syndrome), the level of endorphins also increases slightly(3).
Figure1 Formula of a-Endorphin
Figure 2 mechanism of endorphin to inhibit LHRH release
Ref:
1. Oswald Steward: Functional neuroscience (2000), page 116.
2. Goldstein A, Lowery PJ (September 1975). "Effect of the opiate antagonist naloxone on body temperature in rats". Life Sciences 17 (6): 927–31.
3. Simantov R, Snyder S (1976). "Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor". Proc Natl Acad Sci USA 73 (7): 2515–9.
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都在使用什么牌子型号的这类仪器,用着如何?多多给些建议哦<:)>
要想买几个金属浴，没有特殊要求，只要体积小、请便易携就行。最好是国内主流牌子，样子要好看点的。进口的太贵了。
想H2O3系列的，天根什么的靠谱吗
干式恒温器是采用微电脑控制和半导体制冷技术制造的一款恒温金属浴产品，仪器可配置多种模块，可广泛应用于样品的保存、各种酶的保存和反应、核酸和蛋白质的变性处理、PCR反应、电泳的预变性和血清凝固等。以下为其使作操作方法：
一、开机前检查
电源线插头已经可靠插入电源插座中，电源线接地可靠。
二、温度设置
(1)打开电源开关，所有的指示灯和数码管都亮。大约5秒后即时温度显示窗(PV)显示的数字为金属模块的即时温度，设置温度显示窗(SV)显示的数字为上一次使用的设置温度。
(2)按压(设置/SET)键一次，此时设置温度显示窗(SV)最左边数字闪烁，用上下键可更改闪烁数字到所需数值。
(3)再按压(设置/SET)键一次，闪烁数字右移一位，用上下键更改闪烁数字直至所需数值。
(4)再按压(设置/SET)键一次，闪烁数字右移一位，同样用上下键更改闪烁数字直至所需数值，完成温度的设置工作。或再次按压(设置/SET)键又从左边重新开始设置。
(5)温度设置完成后8秒，数字闪烁现象消失，表示本机系统进入运行状态，并按照当前设定的温度值运转。
三、注意事项
(1)每次使用前和使用以后，必须用棉签沾蒸馏水清洗模块的锥孔，以保证试管与锥孔壁接触充分。
(2)在设置新的温度过程中，本机系统是仍然按照上次设定的温度值运行，直至SV窗口闪烁数字停止。
(3)如果显示温度(PV)与第三方测量温度相差0.1℃以上时，联系本机保管人进行温度误差校正。
(4)在使用恒温器的过程中，禁止按压(校准/ADJ)键。
(5)如果使用在4℃恒温4小时以上的实验操作以后，必须清除模块冷凝水。方法是：拔下电源插头切断电源，然后拧开模块上两个黑色旋钮，取出模块，用软布清除各个接触面的冷凝水，然后再将模块安装复位。
第一步： 选择适用温度
了解样品最佳的实验温度，温度范围越大，相应仪器的价格也就越高，确认好了温度就可以进行下一步了。
第二步：选择试管加热类型
现有的加热类型主要分为两大类：
1 水浴：水浴最高温度在100℃
2 干浴(或称金属浴)：可选择的温度范围在100℃-250℃之间。
水浴优势：介质导热性好
水浴劣势：易污染
干式优势：洁净，使用方便
干式劣势：模块间存在极小的温差
第三步：选择模块
量一下需要使用的试管尺寸及使用数量，然后找到对应的模块。
氮吹仪就简单的选择好啦~~~
对于有更复杂功能的用户来说，只需要在提出自己的需求就好啦。
甲基硅油盐浴、磷酸浴、金属浴.十溴二苯乙烷 磷酸-三（2,3-二氯丙烷）酯1,2,3,4-四溴丁烷1,2-双（2,4,6-三溴苯氧基）乙烷
沥青:沸点(℃)：3000 °C (decomp)
La2O3:Boiling point 4200°C (4500 K)
Lu2O3:Boiling point 3980°C
ThO2:Boiling point 4400°C
