| Oxipurinolxanthine oxidoreductase inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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| Cas No. | 2465-59-0 | SDF | Download SDF |
| Synonyms | Alloxanthine|NSC 76239 | ||
| Chemical Name | 1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | ||
| Canonical SMILES | O=C1C2=C(NN=C2)NC(N1)=O | ||
| Formula | C5H4N4O2 | M.Wt | 152.1 |
| Solubility | ≤3mg/ml in DMSO | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Oxipurinol is a xanthine oxidoreductase inhibitor.
Xanthine oxidoreductase (XO), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. XO is generally recognized as a critical enzyme in purine catabolism.
In vitro: Allopurinol could be rapidly oxidized by XO to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit XO. Oxypurinol was identified as a noncompetitive inhibitor of XO; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. Moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable XO activities [1].
In vivo: Animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].
Clinical trial: The PK parameters of oxypurinol in subjects with normal renal function were found to be t((1/2)) of 23.3 +/- 6.0 hours, CL/F of 0.31 +/- 0.07 mL/min/kg, V(d)/F of 0.59 +/- 0.16 L/kg, and renal clearance relative to creatinine clearance. Oxypurinol has been found to be cleared almost entirely by urinary excretion and, thus the dosage of allopurinol should be reduced in renal impairment [2].
References:[1] P. Pacher, A. Nivorozhkin and C. Szabó. Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol. Pharmacological Reviews 58(1), 87-114 (2006).[2] Day RO, Graham GG, Hicks M, McLachlan AJ, Stocker SL, Williams KM. Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin Pharmacokinet. 2007;46(8):623-44.
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做的比较好的，一般都是上海地区的，你可以看下基尔顿生物。
干式恒温器是采用微电脑控制和半导体制冷技术制造的一款恒温金属浴产品，仪器可配置多种模块，可广泛应用于样品的保存、各种酶的保存和反应、核酸和蛋白质的变性处理、PCR反应、电泳的预变性和血清凝固等。以下为其使作操作方法：
一、开机前检查
电源线插头已经可靠插入电源插座中，电源线接地可靠。
二、温度设置
(1)打开电源开关，所有的指示灯和数码管都亮。大约5秒后即时温度显示窗(PV)显示的数字为金属模块的即时温度，设置温度显示窗(SV)显示的数字为上一次使用的设置温度。
(2)按压(设置/SET)键一次，此时设置温度显示窗(SV)最左边数字闪烁，用上下键可更改闪烁数字到所需数值。
(3)再按压(设置/SET)键一次，闪烁数字右移一位，用上下键更改闪烁数字直至所需数值。
(4)再按压(设置/SET)键一次，闪烁数字右移一位，同样用上下键更改闪烁数字直至所需数值，完成温度的设置工作。或再次按压(设置/SET)键又从左边重新开始设置。
(5)温度设置完成后8秒，数字闪烁现象消失，表示本机系统进入运行状态，并按照当前设定的温度值运转。
三、注意事项
(1)每次使用前和使用以后，必须用棉签沾蒸馏水清洗模块的锥孔，以保证试管与锥孔壁接触充分。
(2)在设置新的温度过程中，本机系统是仍然按照上次设定的温度值运行，直至SV窗口闪烁数字停止。
(3)如果显示温度(PV)与第三方测量温度相差0.1℃以上时，联系本机保管人进行温度误差校正。
(4)在使用恒温器的过程中，禁止按压(校准/ADJ)键。
(5)如果使用在4℃恒温4小时以上的实验操作以后，必须清除模块冷凝水。方法是：拔下电源插头切断电源，然后拧开模块上两个黑色旋钮，取出模块，用软布清除各个接触面的冷凝水，然后再将模块安装复位。
第一步： 选择适用温度
了解样品最佳的实验温度，温度范围越大，相应仪器的价格也就越高，确认好了温度就可以进行下一步了。
第二步：选择试管加热类型
现有的加热类型主要分为两大类：
1 水浴：水浴最高温度在100℃
2 干浴(或称金属浴)：可选择的温度范围在100℃-250℃之间。
水浴优势：介质导热性好
水浴劣势：易污染
干式优势：洁净，使用方便
干式劣势：模块间存在极小的温差
第三步：选择模块
量一下需要使用的试管尺寸及使用数量，然后找到对应的模块。
氮吹仪就简单的选择好啦~~~
对于有更复杂功能的用户来说，只需要在提出自己的需求就好啦。
