| Oxipurinolxanthine oxidoreductase inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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| Cas No. | 2465-59-0 | SDF | Download SDF |
| Synonyms | Alloxanthine|NSC 76239 | ||
| Chemical Name | 1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | ||
| Canonical SMILES | O=C1C2=C(NN=C2)NC(N1)=O | ||
| Formula | C5H4N4O2 | M.Wt | 152.1 |
| Solubility | ≤3mg/ml in DMSO | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Oxipurinol is a xanthine oxidoreductase inhibitor.
Xanthine oxidoreductase (XO), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. XO is generally recognized as a critical enzyme in purine catabolism.
In vitro: Allopurinol could be rapidly oxidized by XO to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit XO. Oxypurinol was identified as a noncompetitive inhibitor of XO; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. Moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable XO activities [1].
In vivo: Animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].
Clinical trial: The PK parameters of oxypurinol in subjects with normal renal function were found to be t((1/2)) of 23.3 +/- 6.0 hours, CL/F of 0.31 +/- 0.07 mL/min/kg, V(d)/F of 0.59 +/- 0.16 L/kg, and renal clearance relative to creatinine clearance. Oxypurinol has been found to be cleared almost entirely by urinary excretion and, thus the dosage of allopurinol should be reduced in renal impairment [2].
References:[1] P. Pacher, A. Nivorozhkin and C. Szabó. Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol. Pharmacological Reviews 58(1), 87-114 (2006).[2] Day RO, Graham GG, Hicks M, McLachlan AJ, Stocker SL, Williams KM. Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin Pharmacokinet. 2007;46(8):623-44.
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想用96孔板，酶标仪来测定，一来量大，二来试剂用量小，
可是遇到一个问题，在使用说明书中要37度水浴5分钟，
请问大家我怎么96孔板水浴啊，先谢谢各位了！！
有什么其他方法来代替水浴啊～！
都在使用什么牌子型号的这类仪器,用着如何?多多给些建议哦<:)>
做的比较好的，一般都是上海地区的，你可以看下基尔顿生物。
第一步： 选择适用温度
了解样品最佳的实验温度，温度范围越大，相应仪器的价格也就越高，确认好了温度就可以进行下一步了。
第二步：选择试管加热类型
现有的加热类型主要分为两大类：
1 水浴：水浴最高温度在100℃
2 干浴(或称金属浴)：可选择的温度范围在100℃-250℃之间。
水浴优势：介质导热性好
水浴劣势：易污染
干式优势：洁净，使用方便
干式劣势：模块间存在极小的温差
第三步：选择模块
量一下需要使用的试管尺寸及使用数量，然后找到对应的模块。
氮吹仪就简单的选择好啦~~~
对于有更复杂功能的用户来说，只需要在提出自己的需求就好啦。
要想买几个金属浴，没有特殊要求，只要体积小、请便易携就行。最好是国内主流牌子，样子要好看点的。进口的太贵了。
想H2O3系列的，天根什么的靠谱吗
