| Conoidin Aperoxiredoxin II inhibitor |
Sample solution is provided at 25 µL, 10mM.
Quality Control & MSDS
- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
Related Biological Data
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| Cas No. | 18080-67-6 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | 2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide | ||
| Canonical SMILES | [O-][N+]1=C(CBr)C(CBr)=[N+]([O-])C2=C1C=CC=C2 | ||
| Formula | C10H8Br2N2O2 | M.Wt | 348.0 |
| Solubility | ≥34.8mg/mL in DMSO | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Conoidin A is a covalent inhibitor of peroxiredoxin II with IC50 value of 23 μM [2].
Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and signal transduction, and changes in PrxII expression are associated with a variety of human diseases, including cancer [1].
Conoidin A is a novel, cell-permeable and covalent peroxiredoxin II inhibitor with IC50 value of 23 μM [1][2]. Conoidin A bound covalently to the peroxidatic cysteine of the T. gondii enzyme peroxiredoxin II (TgPrxII), inhibiting its enzymatic activity. In human epithelial cells, Conoidin A inhibited hyperoxidation of human PrxII [1]. Conoidin A also inactivated AcePrx-1 (a peroxiredoxin from the hookworm Ancylostoma ceylanicum) by alkylating or crosslinking the catalytic cysteines with IC50 value of 374 μM [2]. Conoidin A inhibited the hyperoxidation of two mammalian peroxiredoxin homologues (PrxI and PrxII) in cells [3].
References:[1]. Haraldsen JD1, Liu G, Botting CH, et al. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048.[2]. Nguyen JB1, Pool CD, Wong CY, et al. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22;20(8):991-1001.[3]. Liu G, Botting CH, Evans KM, et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5.
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想用96孔板，酶标仪来测定，一来量大，二来试剂用量小，
可是遇到一个问题，在使用说明书中要37度水浴5分钟，
请问大家我怎么96孔板水浴啊，先谢谢各位了！！
有什么其他方法来代替水浴啊～！
都在使用什么牌子型号的这类仪器,用着如何?多多给些建议哦<:)>
做的比较好的，一般都是上海地区的，你可以看下基尔顿生物。
第一步： 选择适用温度
了解样品最佳的实验温度，温度范围越大，相应仪器的价格也就越高，确认好了温度就可以进行下一步了。
第二步：选择试管加热类型
现有的加热类型主要分为两大类：
1 水浴：水浴最高温度在100℃
2 干浴(或称金属浴)：可选择的温度范围在100℃-250℃之间。
水浴优势：介质导热性好
水浴劣势：易污染
干式优势：洁净，使用方便
干式劣势：模块间存在极小的温差
第三步：选择模块
量一下需要使用的试管尺寸及使用数量，然后找到对应的模块。
氮吹仪就简单的选择好啦~~~
对于有更复杂功能的用户来说，只需要在提出自己的需求就好啦。
要想买几个金属浴，没有特殊要求，只要体积小、请便易携就行。最好是国内主流牌子，样子要好看点的。进口的太贵了。
想H2O3系列的，天根什么的靠谱吗
