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ProductDetails
CatalogNo./Size: | GMH0251F-025/25Tests GMH0251F-100/100Tests | |
Vol.per.Test: | 10μl/Test | |
Clone: | GM1CD25 | |
Isotype: | MouseIgG2a | |
Reactivity: | Human,Notyettestedinotherspecies. | |
Workshop: | N/A | |
StorageBuffer: | Phosphate-bufferedsolution,pH7.4,containing0.09%sodiumazideand0.2%(w/v)BSA | |
StorageCondition: | Storeat4�C.DONOTFREEZE.LIGHTSENSITIVEMATERIAL. | |
Applications: | FlowCytometry | |
ApplicationsNotes: | FACS:Use10µlfor106cells | |
Description: | GM1CD25reactswithCD25antigen,achainoflow-affinityinterleukin-2receptor(IL-2Ra),whichisexpressedonactivatedcellsincludingT,B,NKcellsandmonocytes.Theantigenalsoprsentonsubsetofthymocytes,HTLV-1transformedTcelllines,EBVtransformedBcells,myeloidprecursorsandoligodendrocytes.ThehighaffinityIL-2receptorisformedbythenoncovalentassociationofofa(55kDa,CD25),b(75kDa,CD122),andgsubunit(70kDa,CD132).TheinteractionofIL-2withIL-2RinducestheactivationandproliferationofT,B,NKcellsandmacrophages.CD4+/CD25+cellsmightdirectlyregulatethefunctionofresponsiveTcells. |