A 1:250 dilution of SPC-1121 was sufficient for detection of DUSP2 in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Biological Description
Alternative Names
Dual specificity phosphatase 2 antibody, Dual specificity protein phosphatase 2 antibody, Dual specificity protein phosphatase PAC 1 antibody, Dual specificity protein phosphatase PAC-1 antibody, DUS2_HUMAN antibody, DUSP 2 antibody, DUSP2 antibody, PAC 1 antibody, PAC1 antibody, Serine/threonine specific protein phosphatase antibody
Cellular Localization
Nucleus
Accession Number
NP_004409
Gene ID
1844
Swiss Prot
Q05923
Scientific Background
DUSP2 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
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Biotin
Properties:
Binds tetrameric avidin proteins including Streptavidin and neuravidin with very high affinity
Molar mass: 244.31 g/mol
Formula: C10H16N2O3S
Applications: Western blot, immunohistochemistry, and ELISA
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