BiologicalActivity
Potent,orallyactiveATP-competitivetransforminggrowthfactor-βreceptor1(TGF-βRI)inhibitor(IC50=49nM).Displays>100-foldand>17-foldselectivityoverTGF-βRIIandothercommonkinasesrespectively.Exhibitsanti-inflammatoryandantitumoractivity.Alsopromotesanantigliomaimmuneresponse.Amelioratesgerminalmatrixhemorrhage-inducedneurologicaldeficitsinneonatalrats.
CompoundLibraries
SD208isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 352.75 |
| Formula | C17H10ClFN6 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 627536-09-8 |
| PubChemID | 10316032 |
| InChIKey | BERLXWPRSBJFHO-UHFFFAOYSA-N |
| Smiles | FC(C=CC(Cl)=C3)=C3C2=NC1=NC=CN=C1C(NC4=CC=NC=C4)=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.05 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight352.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.83mL | 14.17mL | 28.35mL |
| 5mM | 0.57mL | 2.83mL | 5.67mL |
| 10mM | 0.28mL | 1.42mL | 2.83mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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