Rabbitpolyclonalantibody
PooledSerum- Size:
- 100µl
- Formulation:
- AffinityPurifiedfromPooledSerum
- Specificity:
- Rat,Mouse,Human,Xenopus,Bovine,Zebrafish
- Applications:
- WB1:1000IHC1:500
- Species:
- Rabbit
- GeneName:
- SYN1
- MolecularReference:
- ~78kDa
- CiteThisAntibody:
- PhosphoSolutionsCat#p1560-9,RRID:AB_2492244
Antigen/Purification:Collapse
Theantigenisaphosphopeptidecorrespondingtoaminoacidresiduessurroundingthephospho-Ser9ofsynapsinI.
Theantibodyispreparedfrompooledrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephospho-peptideaffinitycolumns.
BIOLOGicalSignificance:Collapse
SynapsinIplaysakeyroleinsynapticplasticityinbrain(Fengetal.,2002;Nayaketal.,1996).ThiseffectisdueinlargeparttotheABIlityofthesynapsinstoregulatetheavailabilityofsynapticvesiclesforrelease.Inadditiontoitsroleinplasticity,theexpressionofsynapsinIisapreciseindicatorofsynapseformation(MooreandBernstein,1989;Stoneetal.,1994).Thus,synapsinIimmunocytochemistryprovidesavaluabletoolforthestudyofsynaptogenesis.Theroleofsynapsininsynapticplasticityandinsynaptogenesisisregulatedbyphosphorylation(Jovanovicetal.,2001;Kaoetal.,2002).Serine9isthesiteonsynapsinIthatisphosphorylatedbycAMP-dependentproteinkinaseandbycalciumcalmodulinkinaseI(Czerniketal.,1987).Phosphorylationofthissiteisthoughttoregulatesynapticvesiclefunctionandneuriteoutgrowth(Kaoetal.,2002).
Storage
100µlin10mMHEPES(pH7.5),150mMNaCl,100µgpermlBSAand50%glycerol.Adequateamountofmaterialtoconduct10-miniWesternBlots.
Forlongtermstorage–20°Cisrecommended.Stableat–20°Cforatleast1year.
ProductSpecificReferences
Benleulmi‐Chaachoua,A.,Chen,L.,Sokolina,K.,Wong,V.,Jurisica,I.,Emerit,M.B.,Darmon,M.,Espin,A.,Stagljar,I.,Tafelmeyer,P.,Zamponi,G.W.,Delagrange,P.,Maurice,P.,&Jockers,R.(2015).ProteininteractomeminingdefinesmelatoninMT1receptorsasintegralcomponentofpresynapticproteincomplexesofneurons.JournalofPinealResearch.PMID:26514267
YoavShulman,AlexandraStavsky,TatianaFedorova,DanMikulincer,MeravAtias,IgalRADInsky,JoyKahn,InnaSlutsky,DanielGitler.(2015).ATPBindingtoSynapsinIIaRegulatedUsageandClusteringofVesiclesinTerminalsofHippocampalNeurons.J.Neuro,35(3):985-998.PMID:25609616
SachikoShimomura,TadashiNagamine,NaoyaHatano,NoriyukiSueyoshi,andIsamuKameshita(2010)Identificationofanendogenoussubstrateofzebrafishdoublecortin-likeproteinkinaseusingahighlyactivetruncationmutant.J.Biochem.,147:711–722.PMID:20097902
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慢性淋巴细胞性甲状腺炎亦称桥本甲状腺炎，是一种自体免疫性疾病。
本病多见于中年女性，表现为甲状腺肿，起病缓慢，常在无意中发现，体积约为正常甲状腺的2～3倍，表面光滑，质地坚韧有弹性如橡皮，明显结节则少见，无压痛，与四周无粘连，可随吞咽运动活动。
若出现甲状腺机能亢进症的表现时，宜吃得清淡，吃含维生素高的新鲜蔬菜、水果及营养丰富的瘦肉、鸡肉、鸭肉、甲鱼、淡水鱼、香菇、银耳、百合、桑椹等食物。忌食碘、辣椒、羊肉、浓茶、咖啡等湿热或具有刺激性的食物。
若出现甲状腺机能减退症的表现时，除忌碘外，宜吃含维生素高的新鲜的蔬菜、水果，还宜胡桃肉、枸杞子、山药、芡实等食物。
其主要作用就是人体的防御军队，抵抗外来的病毒、细菌的侵袭。
抗体都是免疫球蛋白而免疫球蛋白不一定都是抗体。原因是抗体是由浆细胞产生，且能与相应抗原特异性结合发挥免疫功能的球蛋白。而免疫球蛋白是具有抗体活性或化学结构与抗体相似的球蛋白，如骨髓瘤患者血清中异常增高的骨髓瘤蛋白，是由浆细胞瘤产生，其结构与抗体相似，但无免疫功能。因此，免疫球蛋白可看做是化学结构上的概念，抗体则是生物学功能上的概念。
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