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Theanti-Cyclin-DependentKinase4(Cdk4)antibodyreactsspecificallywithcdk4proteinpresentpredominantlyinG1phaseofcellcycle;itdoesnotcross-reactwithcyclins.Onfrozensectionsofheadandneckcarcinoma(oropharynxandhypopharynxcarcinoma)Theanti-Cyclin-DependentKinase4monoclonalDCS-156antibodyshowsdistinctnuclearstaining.