SUMITOMO CHEMICAL ASIA PTE LTD_工商信息_信用报告_财务报表...
货号: | E-AB-31711 |
抗体英文名: | hnRNPHPolyclonalAntibody |
应用范围: | WB,IHC-p,ELISA |
宿主: | Rabbit |
适应物种: | Human,Mouse,Rat |
克隆性: | 否 |
保存条件: | Storeat-20℃.Avoidfreeze/thawcycles. |
亚型: | IgG |
免疫原: | SynthesizedpeptidederivedfromtheInternalregionofhumanhnRNPH |
规格: | 30μL/60μL/120μL |
Synonyms | HNRNPH1,HNRPH,HNRPH1,HeterogeneousnuclearribonucleoproteinH,hnRNPH,HNRNPH2,FTP3,HNRPH2,HeterogeneousnuclearribonucleoproteinH2,hnRNPH2,FTP-3,HeterogeneousnuclearribonucleoproteinH,hnRNPH |
Swissprot | P31943/P55795 |
GeneID | 3188 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | SynthesizedpeptidederivedfromtheInternalregionofhumanhnRNPH |
Application | WB,IHC-p,ELISA |
Recommendeddilution | WB1:500-1:2000,IHC1:100-1:300,ELISA1:20000 |
Concentration | 1mg/mL |
Clonality | Polyclonal |
ResearchAreas |
Properties
Isotype | IgG |
Purification | Affinitypurification |
Conjugation | Unconjugated |
CalculatedMV | 49kDa |
ObservedMV | 49kDa |
Storageinstructions | Storeat-20℃.Avoidfreeze/thawcycles. |
Storagebuffer | PBSwith0.02%sodiumazide,0.5%BSAand50%glycerol,pH7.4 |
Background | HNRNPH1encodesamemberofasubfamilyofubiquitouslyexpressedheterogeneousnuclearribonucleoproteins(hnRNPs).ThehnRNPsareRNAbindingproteinsthatcomplexwithheterogeneousnuclearRNA.Theseproteinsareassociatedwithpre-mRNAsinthenucleusandappeartoinfluencepre-mRNAprocessingandotheraspectsofmRNAmetabolismandtransport.WhileallofthehnRNPsarepresentinthenucleus,somemayshuttlebetweenthenucleusandthecytoplasm.ThehnRNPproteinshavedistinctnucleicacidbindingproperties.Theproteinencodedbythisgenehasthreerepeatsofquasi-RRMdomainsthatbindtoRNAandisverysimilartothefamilymemberHNRPF.ThisgenemaybeassociatedwithhereditarylymphedematypeI.Alternativelysplicedtranscriptvariantshavebeendescribed.HNRNPH1(HeterogeneousNuclearRibonucleoproteinH1)isaProteinCodinggene.DiseasesassociatedwithHNRNPH1includePrecursorT-CellAcuteLymphoblasticLeukemiaandHereditaryLymphedema.AmongitsrelatedpathwaysaremRNASplicing-MajorPathwayandGeneExpression.GOannotationsrelatedtothisgeneincludenucleicacidbindingandRNAbinding.AnimportantparalogofthisgeneisHNRNPH2. HNRNPH2belongstothesubfamilyofubiquitouslyexpressedheterogeneousnuclearribonucleoproteins(hnRNPs).ThehnRNPsareRNAbindingproteinsandtheycomplexwithheterogeneousnuclearRNA(hnRNA).Theseproteinsareassociatedwithpre-mRNAsinthenucleusandappeartoinfluencepre-mRNAprocessingandotheraspectsofmRNAmetabolismandtransport.WhileallofthehnRNPsarepresentinthenucleussomeseemtoshuttlebetweenthenucleusandthecytoplasm.ThehnRNPproteinshavedistinctnucleicacidbindingproperties.Theproteinencodedbythisgenehasthreerepeatsofquasi-RRMdomainsthatbindstoRNAs.ItisverysimilartothefamilymemberHNRPH1.ThisgeneisthoughttobeinvolvedinFabraydiseaseandX-linkedagammaglobulinemiaphenotype.Alternativesplicingresultsinmultipletranscriptvariantsencodingthesameprotein.Read-throughtranscriptionbetweenthislocusandtheribosomalproteinL36agenehasbeenobserved.HNRNPH2(HeterogeneousNuclearRibonucleoproteinH2)isaProteinCodinggene.DiseasesassociatedwithHNRNPH2includeMentalRetardation,X-Linked,Syndromic,BainType.AmongitsrelatedpathwaysaremRNASplicing-MajorPathwayandGeneExpression.GOannotationsrelatedtothisgeneincludenucleicacidbindingandRNAbinding.AnimportantparalogofthisgeneisHNRNPH1. |
Image

WesternBlotanalysisofvariouscellswithhnRNPHPolyclonalAntibody.
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发布于 : 2017-08-30
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