请使用支持JavaScript的浏览器! 万华化学“化敌为友”,9.25亿收购“搅局者”瑞典国际化工_康乃尔_蚂蚁淘,【正品极速】生物医学科研用品轻松购|ebiomall -蚂蚁淘商城
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万华化学“化敌为友”,9.25亿收购“搅局者”瑞典国际化工_康乃尔
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Prolactin(PRL)isaneuroendocrinepituitaryhormone.Prolactinissynthesizedbytheanteriorpituitary,placenta,brain,uterus,dermalfibroblasts,decidua,Bcells,Tcells,NKcellsandbreastcancercells.Originallycharacterizedasalactogenichormone,furtherstudieshavedemonstratedbroaderrolesinbreastcancerdevelopment,regulationofreproductivefunction,andimmunoregulation.Intheimmunesystem,ProlactinhasbeenshowntobesecretedbyhumanPBMCandtoactasaproliferativegrowthfactor.Additionally,ProlactintreatmentofhumanPBMChasbeenshowntoenhanceIFNγproduction.Inthebreast,Prolactin-inducedmorphogenesisofthemammarycellsismediatedthroughIGF2,whichinturnup-regulatescyclinD1.Prolactinhasseveralmolecularforms.Thepredominantformisamonomer;thenon-glycosylatedformis23kDaandtheglycosylatedformis25kDa.GlycosylatedProlactinisremovedfromthecirculationfasterandhasbeenreportedtohavelowerbiologicalpotency.MouseProlactincDNAencodesa228aminoacid(aa)residueproteinwithaputative31aaresiduesignalpeptide.TheProlactinreceptorisatransmembranetypeIglycoproteinthatbelongstothecytokinehematopoieticreceptorfamily.Bcells,Tcells,macrophages,NKcells,monocytes,CD34+progenitorcells,neutrophils,mammarygland,liver,kidney,adrenals,ovaries,testis,prostrate,seminalvesicles,andhypothalamushaveallbeenshowntoexpresstheProlactinreceptor.Threeformsofthereceptor,generatedbydifferentialsplicing,havebeenidentified.Theseisoformsdifferinthelengthoftheircytoplasmicdomains.Itisbelievedthattheshortcytoplasmicformisnonfunctional.ProlactinsignaltransductioninvolvestheJAK/STATfamiliesandSrckinasefamily.
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