
Purity: | Affinity purification |
Storage: | Store at 4 or -20°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
EZH2 is a lysine specific methyltransferase, acting mainly as a gene silencer. EZH2 performs this role by the addition of methyl groups to lysine 27 of histone H3, a modification leading to chromatin condensation (1). EZH2 over expression may promote cancer due to increase in histone methylation which silence the expression of tumor suppressor genes (2). EZH2 inhibitor EPZ-6438 and GSK126 is under clinical research, presenting good small molecule tools for EZH2 study (3,4). EZH2 antibody detects EZH2 enzyme and presents a good tool to study this protein.
- PDF:
EZH2-xcessbio.pdf
- SDS:
SDS_EZH2_Polyclonal_Antibdoy.pdf
Reference:
- 1. Cao R et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing (2002) Science 298(5595):1039–43.
- 2. Suvà ML et al. EZH2 is essential for glioblastoma cancer stem cell maintenance. (2009) Cancer Res. 69(24):9211–8.
- 3. McCabe MT, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. (2012) Nature. 492(7427):108-12.
- 4. Knutson SK, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. (2013) Proc Natl Acad Sci U S A. 110(19):7922-7.
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
第二个问题:兔子不能免疫兔子的。免疫的一个重要概念是识别“自己”和“非己”,如果对自己的蛋白产生免疫反应,那就麻烦了。
可以类比器官移植,亲缘关系越近,越不容易产生免疫排斥。
你看这个抗体的质量怎么样,说明里面有没有说可以做组化,还是只能做western blot。
sc-153是兔抗大鼠ERK2的多克隆抗体
还有很多关于ERK1和ERK2的抗体
若想知道更多信息,你可以拨打Santa cruz 上海分公司的电话咨询
021-6093-6351
我们会按照你的实验需求推荐最适合你的产品。
想买消炎药怎么办?
去药店买药想买不是抗生素的消炎药,那工作人员说不是抗生素怎么消炎呢,请问知情网友求一替代品,谢了。
以下来自摆渡百科
细胞在发生凋亡时,会激活一些DNA内切酶,这些内切酶会切断核小体间的基因组DNA。细胞凋亡时抽提DNA进行电泳检测,可以发现180-200bp的DNA ladder。基因组DNA断裂时,暴露的3’-OH可以在末端脱氧核苷酸转移酶(Terminal
Deoxynucleotidyl Transferase, TdT) 的催化下加上荧光素 (FITC) 标记的dUTP
(fluorescein-dUTP) ,从而可以通过荧光显微镜或流式细胞仪进行检测,这就是TUNEL (TdT-mediated dUTP
Nick-End Labeling) 法检测细胞凋亡的原理。

