mCalpain and friends in Cell motility(2)|and|cell|friends|in|...
| ProductDetails | |
|---|---|
| Synonyms | CPSD;CTSD;EC=3.4.23.5 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | AF4G5 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-CathepsinDproteinpurifiedfromE.coli. |
| Application | WesternBlot(1:500~1:2,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CathepsinD(CatD)isaubiquitouslyexpressedlysosomalaspartylproteaseinvolvedinthenormaldegradationofproteinsapoptosisandautophagy.HumanCatDissynthesizedontheendoplasmicreticulumasapre-pro-enzyme.PreprocathepsinD(412aa)iscleavedandglycosylatedtoformaninactiveprocathepsinD(392aa)andthenfurthercleavedtogenerateanactiveintermediate(348aa)single-chainmolecule.TheactiveintermediateisfurtherprocessedintomaturetwochainformofcathepsinD,thisprocessingstepiscarriedoutbycathepsinBorL.Thetwo-chainformconsistsofanaminoterminallightchainandacarboxyl-terminalheavychain.Additionally,severalmoreaminoacidsareremovedfromthecarboxylterminusoftheheavychain.ProcathepsinD(pCD),secretedfromcancercells,actsasamitogenonbothcancerandstromalcellsandstimulatestheirproinvasiveandpro-metastaticproperties.Acidproteaseactiveinintracellularproteinbreakdown.InvolvedinthepathogenesisofseveraldiseasessuchasbreastcancerandpossIBLyAlzheimerdisease
ProductReferences
1)ZaidiNetal.,(2008)BiochemBiophysResCommun7;376(1):5-9.(General)
2)Liaudet-CoopmanEetal.,(2006)CancerLett237;167-179.(General)
2)Liaudet-CoopmanEetal.,(2006)CancerLett237;167-179.(General)
免责声明 本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容。
版权声明 未经蚂蚁淘授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘”。违反上述声明者，本网将追究其相关法律责任。
发布于 ： 2021-08-09
阅读（197）
▍
相关分类
▍
相关文章
SCI期刊MATERIALE PLASTICE(00255289)影响因子
N1019 N1014 TriLink BioTechnologies 核酸修饰专家
生物素标记抗体的免疫荧光方法
人副甲状旁腺激素相关肽(PTHrp)ELISA试剂盒说明书__供应信息_中国...
Cerilliant健竹生物
超声破碎仪探头选择
【求助】PCR技术、原位PCR、原位杂交技术有什么区别及优缺点？ ...
Human Alpha 1 Acid Glycoprotein / AGP ELISA Kit (AGP)
都是猫抓惹的祸_医生
v2的干拉参数，link混战服kd1.75左右，带脑子的拉 ...
...山羊抗人IgA+IgG+IgM(H+L)二抗| TRITCconjugated AffiniPure...
mCalpain and friends in Cell motility(2)|and|cell|friends|in|...
▍
相关问答
