TheMAR1-5A3monoclonalantibodyreactswithmouseIFNAR-1(IFNalpha/betareceptorsubunit1).IFNAR-1iscoexpressedwithIFNAR-2onnearlyallcelltypesandtogetherthesetwosubunitsmakeuptheheterodimericTypeIIFNReceptorcomplex.TypeIIFNs(IFN-α/β)bindtotheTypeIIFNReceptorcomplextoinducecellularresponsesincludinginductionofanti-viral,anti-microbial,anti-tumor,andautoimmuneresponsesaswellastoregulatetheactivation,proliferation,anddifferentiationofmanycelltypes.TheMAR1-5A3antibodyhasbeenshowntoinhibitTypeIIFNreceptorsignalinginvitroandinvivo.
Isotype | MouseIgG1 |
RecomendedIsotypeControl(s) | InVivoPlusmouseIgG1isotypecontrol,unknownspecificity |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
Immunogen | ExtracellulardomainofmouseIFNAR-1 |
ReportedApplications |
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Endotoxin |
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Purity |
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Aggregation |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Undilutedat4°Cinthedark |
MurinePathogenTestResults |
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