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Schircks特约代理

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TheYTS169.4monoclonalantibodyreactswithmouseCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.TheYTS169.4antibodyexhibitsdepletingactivitywhenusedinvivo.

Isotype	RatIgG2b, κ
RecomendedIsotypeControl(s)	InVivoPlusratIgG2bisotypecontrol,anti-keyholelimpethemocyanin
RecommendedInVivoPureDilutionBuffer	InVivoPurepH7.0DilutionBuffer
Immunogen	CBAmousethymocytes
ReportedApplications	invivoCD8+Tcelldepletion Westernblot
Endotoxin	<1EU/mg(<0.001EU/μg) DeterminedbyLALgelclottingassay
Purity	>95% DeterminedbySDS-PAGE
Aggregation	<5% DeterminedbyDLS
Formulation	PBS,pH7.0 Containsnostabilizersorpreservatives
Sterility	0.2μMfiltered
Production	Purifiedfromtissueculturesupernatantinananimalfreefacility
Purification	ProteinG
Storage	Undilutedat4°Cinthedark
MurinePathogenTestResults	MouseNorovirus:Negative MouseParvovirus:Negative MouseMinuteVirus:Negative MouseHepatitisVirus:Negative ReovirusScreen:Negative LymphocyticChoriomeningitisvirus:Negative LactateDehydrogenase-ElevatingVirus:Negative MouseRotavirus:Negative TheilersMurineEncephalomyelitis:Negative Ectromelia/MousepoxVirus:Negative Hantavirus:Negative PolyomaVirus:Negative MouseAdenovirus:Negative SendaiVirus:Negative MycoplasmaPulmonis:Negative PneumoniaVirusofMice:Negative MouseCytomegalovirus:Negative KVirus:Negative