The53-6.7monoclonalantibodyreactswithmouseCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.The53-6.7antibodyexhibitsdepletingactivitywhenusedinvivo.
Isotype | RatIgG2a, κ |
RecomendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH6.5DilutionBuffer |
Immunogen | MouseSpleenCellsorThymocyteMembranes |
ReportedApplications |
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Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Undilutedat4°Cinthedark |