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| ProductDetails | |
|---|---|
| Synonyms | 12β-Hydroxydigitoxin;NSC95100 |
| ProductType | Chemical |
| Properties | |
| Formula | C41H64O14 |
| MW | 780.94 |
| CAS | 20830-75-5 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitepowder. |
| Solubility | SolubleinDMSO(100mM)ormethanol. |
| Identity | DeterminedbyNMR. |
| Declaration | ManufacturedbyChemodex. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | LTMHDMANZUZIPE-PUGKRICDSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CardiacglycosidefromtheleavesofDigitalislanata.Itisusedtotreatcardiacarrhythmias.ItisoftenusedasamodelsubstrateofP-glycoprotein(Pgp)(0.01-10µM)andaninhibitorofNa+/K+-ATPase.Inhibitsmembrane-boundα-subunitsoftheNa+/K+ATPasepumpinmyocytes.TheprimarymechanismofactioninvolvesinhibitionoftheNa+/K+ATPase,mainlyinthemyocardium.Thisinhibitioncausesanincreaseinintracellularsodiumlevels,resultinginareversaloftheactionofthesodium-calciumexchanger,whichcausesanincreaseintheintracellularcalciumconcentration.Thisleadstoadecreaseinheartrateandincreasedstorageofcalciuminthesarcoplasmicreticulum,causingacorrespondingincreaseinthereleaseofcalciumduringeachactionpotential.
ProductReferences
(1)R.G.Woolfson,etal.;KidneyInt.46,297(1994)|(2)S.Reddy,etal.;Curr.Opin.Cardiol.12,233(1997)|(3)K.Kjeldsen&H.Bundgaard;Ann.NYAcad.Sci.986,702(2003)|(4)M.Gheorghiade,etal.;Circulation109,2959(2004)|(5)M.Ehle,etal.;Crit.Pathw.Cardiol.10,93(2011)|(6)R.J.Biggar;Clin.CancerRes.18,2133(2012)|(7)A.M.Nader&D.R.Foster;J.Clin.Pharmacol.54,3(2014)|(8)G.A.Ewy;Am.J.Med.128,1272(2015)
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发布于 ： 2021-09-22
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