
- SpeciesReactivityHuman,Mouse,Rat
- SpecificityDetectshuman,mouse,andratHSPH1.ThisantibodyispredictedtoreactwithHSPH1 alphaand betaisoformsbasedonsequenceidentityoftheimmunogen.
- SourcePolyclonalGoatIgG
- PurificationAntigenAffinity-purified
- ImmunogenE.coli-derivedrecombinantratHSPH1
Val595-Asp733
Accession#Q66HA8 - FormulationLyophilizedfroma0.2μmfilteredsolutioninPBSwithTrehalose.*Smallpacksize(SP)issuppliedasa0.2µmfilteredsolutioninPBS.
- LabelUnconjugated
- WesternBlot0.1µg/mLSeebelow
- Immunohistochemistry5-15µg/mLSeebelow
- ReconstitutionReconstituteat0.2mg/mLinsterilePBS.
- ShippingTheproductisshippedatambienttemperature.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.*Smallpacksize(SP)isshippedwithpolarpacks.Uponreceipt,storeitimmediatelyat-20to-70°C
- StABIlity&StorageUseamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.
- 12monthsfromdateofreceipt,-20to-70°Cassupplied.
- 1month,2to8°Cundersterileconditionsafterreconstitution.
- 6months,-20to-70°Cundersterileconditionsafterreconstitution.
- LongName:HeatShockProteinH1
- EntrezGeneIDs:10808(Human);288444(Rat)
- AlternateNames:AntigenNY-CO-25;heatshock105kDbeta;heatshock105kDaprotein1;heatshock105kDa/110kDaprotein1;Heatshock110kDaprotein;heatshockprotein105kDa;HSP105a;HSP105B;HSP105heatshock105kDalpha;HSP110;HSPH1;KIAA0201DKFZp686M05240;NY-CO-25
Background:
Theheatshockproteins(HSPs)areahighlyconservedfamilyofstressresponseproteins.HSPsfunctionprimarilyasmolecularchaperones,facilitatingthefoldingofothercellularproteins,preventingproteinaggregation,ortargetingimproperlyfoldedproteinstospecificdegradativepathways.HeatShockProteinsareubiquitouslyexpressedinallorganisms.Theyareinducedinresponsetovarioustypesofenvironmentalstresseslikeheat,cold,andoxygendeprivation.HeatshockproteinH1(HSPH1),alsoknownasHSP105andHSP110,existsastwoisoforms,alphaandbeta.HSPH1alphaconsistsof858aminoacidswhereasHSPH1betahas814 aminoacids.alphaandbetahavecalculatedmolecularweightsof96.4kDaand92kDa,respectively,butanapparentmolecularweightof105‑110 kDainSDS‑PAGE.HSPH1actsasachaperonetopreventthermalaggregationinmammaliancells.HSPH1alphaandbetaisoformsshare94%identity.RatHSPH1has92%and97% identitytohumanandmouseHSPH1,respectively.
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