
- SpeciesReactivityHuman
- SpecificityDetectshumanE2F-1indirectELISAsandWesternblots.IndirectELISAs,lessthan1% cross-reactivitywithrecombinanthumanE2F-2,-3,-4,-5,-6,-7,and-8isobserved.
- SourcePolyclonalSheepIgG
- PurificationAntigenAffinity-purified
- ImmunogenE.coli-derivedrecombinanthumanE2F-1
Val264-Phe437
Accession#Q01094 - FormulationLyophilizedfroma0.2μmfilteredsolutioninPBSwithTrehalose.*Smallpacksize(SP)issuppliedasa0.2µmfilteredsolutioninPBS.
- LabelUnconjugated
- WesternBlot1µg/mLSeebelow
- Immunohistochemistry5-15µg/mLSeebelow
- ReconstitutionReconstituteat0.2mg/mLinsterilePBS.
- ShippingTheproductisshippedatambienttemperature.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.*Smallpacksize(SP)isshippedwithpolarpacks.Uponreceipt,storeitimmediatelyat-20to-70°C
- StABIlity&StorageUseamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.
- 12monthsfromdateofreceipt,-20to-70°Cassupplied.
- 1month,2to8°Cundersterileconditionsafterreconstitution.
- 6months,-20to-70°Cundersterileconditionsafterreconstitution.
- LongName:E2FTranscriptionFactor1
- EntrezGeneIDs:1869(Human);13555(Mouse);399489(Rat)
- AlternateNames:E2Ftranscriptionfactor1;E2F1;E2F-1;PBR3;PRB-bindingproteinE2F-1;RBAP1;RBAP-1;RBBP3;RBBP-3;RBP3;Retinoblastoma-associatedprotein1;Retinoblastoma-bindingprotein3;transcriptionfactorE2F1
Background:
E2F-1(adenovirusE2genepromoterregionbindingfactor1;alsoretinoblastoma[RB]-bindingprotein3/RBP3)isa57 - 60 kDanuclearmemberoftheE2F/DPfamilyoftranscriptionfactors.Ithasadualfunction,mediatingbothcellproliferationandapoptosisinacontext-dependentmanner.HumanE2F-1is437 aminoacids(aa)inlength.ItcontainsacyclinA:CDK2bindingsite(aa 67 - 108),aDNA-bindingregion(aa 110 - 194),andanRBproteinbindingmotif(aa 409 - 426)that,whenengaged,inactivatesE2F-1.Thereisonepotentialin-frame23 aasubstitutionforaa 89 - 111.Overaa 264 - 437,humanE2F-1shows89%and80%aa identitytocanineandmouseE2F-1,respectively.
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>


暂无品牌分类