
- SpeciesReactivityHuman
- SpecificityDetectshumanIL-1beta/IL-1F2 inWesternblots.Showslessthan5%cross-reactivitywithrecombinantmouse(rm) IL-1beta/IL-1F2andrecombinantporcineIL-1beta/IL-1F2andnocross-reactivitywithrecombinantrat(rr) IL-1beta/IL-1F2,rmIL‑1alpha,recombinanthumanIL‑1ra,rmIL‑1ra,orrrIL‑1alpha.
- SourceMonoclonalMouseIgG1Clone#8516
- PurificationProteinAorGpurifiedfromhybridomaculturesupernatant
- ImmunogenE.coli-derivedrecombinanthumanIL-1beta/IL-1F2
Ala117-Ser269
Accession#P01584 - FormulationSuppliedinasalinesolutioncontainingBSAandSodiumAzide.
- LabelFluorescein
- IntracellularStainingbyFlowCytometry10µL/106cellsSeebelow
- ShippingTheproductisshippedwithpolarpacks.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.
- StABIlity&StorageProtectfromlight.Donotfreeze.
- 12monthsfromdateofreceipt,2to8°Cassupplied.
- Allan,S.M.etal.(2005)Nat.Rev.Immunol.5:629.
- Boraschi,D.andA.Tagliabue(2006)Vitam.Horm.74:229.
- Kornman,K.S.(2006)Am.J.Clin.Nutr.83:475S.
- Isoda,K.andF.Ohsuzu(2006)J.Atheroscler.Thromb.13:21.
- March,C.J.etal.(1985)Nature315:641.
- Auron,P.E.etal.(1984)Proc.Natl.Acad.Sci.USA 81:7907.
- Martinon,F.andJ.Tschopp(2007)CellDeathDiffer.14:10.
- LongName:Interleukin1beta
- EntrezGeneIDs:3553(Human);16176(Mouse);24494(Rat);397122(Porcine);403974(Canine);100034237(Equine);100135556(GuineaPig)
- AlternateNames:catabolin;IL1beta;IL-1beta;IL-1;IL1B;IL-1b;IL1-BETA;IL-1F2;IL1F2IL-1beta;interleukin1,beta;interleukin-1beta;preinterleukin1beta;pro-interleukin-1-beta
Background:
IL-1isanamethatdesignatestwopleiotropiccytokines,IL-1alpha(IL-1F1)andIL-1beta(IL-1F2),whicharetheproductsofdistinctgenes.IL-1alphaandIL-1betaarestructurallyrelatedpolypeptidesthatshareapproximately21%aminoacid(aa)identityinhuman.Bothproteinsareproducedbyawidevarietyofcellsinresponsetoinflammatoryagents,infections,ormicrobialendotoxins.WhileIL-1alphaandIL-1betaareregulatedindependently,theybindtothesamereceptorandexertidenticalBIOLOGicaleffects.IL-1RIbindsdirectlytoIL-1alphaorIL-1betaandthenassociateswithIL-1RAccessoryProtein(IL-1R3/IL-1RAcP)toformahigh-affinityreceptorcomplexthatiscompetentforsignaltransduction.IL-1RIIhashighaffinityforIL-1betabutfunctionsasadecoyreceptorandnegativeregulatorofIL-1betaactivity.IL-1rafunctionsasacompetitiveantagoNISTbypreventingIL-1alphaandIL-1betafrominteractingwithIL-1RI(1 - 4).ThehumanIL-1betaCDNAencodesa269 aaprecursor.A116 aapropeptideiscleavedintracellularlybythecysteineproteaseIL-1beta-convertingenzyme(Caspase-1/ICE)togeneratetheactivecytokine(5-7).The17kDamaturehumanIL-1betashares96%aasequenceidentitywithrhesusand67-78%withcanine,cottonrat,equine,feline,mouse,porcine,andratIL-1beta.
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>


暂无品牌分类