
- SpeciesReactivityMouse,Rat
- SpecificityDetectsmouseandratButyrylcholinesterase/BCHEin directELISAsandWesternblots.
- SourcePolyclonalGoatIgG
- PurificationAntigenAffinity-purified
- ImmunogenChinesehamsterovarycelllineCHO-derivedrecombinantmouseButyrylcholinesterase/BCHE
His28-Leu603
Accession#AAH99977 - FormulationLyophilizedfroma0.2μmfilteredsolutioninPBSwithTrehalose.*Smallpacksize(SP)issuppliedasa0.2µmfilteredsolutioninPBS.
- LabelUnconjugated
- WesternBlot1µg/mLSeebelow
- Immunohistochemistry5-15µg/mLSeebelow
- ReconstitutionReconstituteat0.5mg/mLinsterilePBS.
- ShippingTheproductisshippedatambienttemperature.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.*Smallpacksize(SP)isshippedwithpolarpacks.Uponreceipt,storeitimmediatelyat-20to-70°C
- StABIlity&StorageUseamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.
- 12monthsfromdateofreceipt,-20to-70°Cassupplied.
- 1month,2to8°Cundersterileconditionsafterreconstitution.
- 6months,-20to-70°Cundersterileconditionsafterreconstitution.
- Darvesh,S.etal.(2003)Nat.Rev.Neuroscience4:131.
- Diamant,S.etal.(2006)Proc.Natl.Acad.Sci.USA103:8628.
- Campbell,V.A.andGowran,A.(2007)Br.J.Pharm.152:655.
- Das,U.N.(2007)MedSciMonit.13:RA214.
- EntrezGeneIDs:590(Human);12038(Mouse)
- AlternateNames:Acylcholineacylhydrolase;BCHE;Butyrylcholineesterase;Butyrylcholinesterase;CHE1;CHE1cholinesterase;CholineesteraseII;cholinesterase1;E1;EC3.1.1.8;Pseudocholinesterase
Background:
Butyrylcholinesterase(BCHE)isamajoracetylcholinehydrolyzingenzymeinthecirculation(1).Althoughitispresentinsignificantamounts(~3 mg/L)inhumanplasma,noendogenousphysiologicalsubstratehasbeendescribedforthisenzyme.Itcandegradealargenumberofester-containingcompoundsinadditiontoacylcholines.Thus,itislikelytoplaysignificantpharmacologicalandtoxicologicalroles.ItisthoughttobeinvolvedinthepathologicalprocessofAlzheimer"sdisease(AD)bydepletingacetylcholine.IncontrasttoACHE,itattenuatesamyloidfibrilformationinvitro(2).BCHEinhibitorshavebeenusedtodelaysymptomsofADpatientsbyvirtueoftheirabilitytoenhanceacetylcholineavailability(3).Itsinvolvementinacholinergicanti-inflammatorypathwayconnectBCHEandACHEwithapossIBLeMarkeroflow-gradesystemicinflammationobservedinType-2diabetes,obesity,hypertension,coronaryheartdisease,andAD(4).BCHEcanexistinmonomericandmultimericforms(1).
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>


暂无品牌分类