


Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.

ThisantibodyisshippedwithitsantigenFREEofcharge!
- PeptideMDEEEDGAGAEESGQPRSFTQL(C),correspondingtoaminoacidresidues1-22ofratCACNA1G (Accession O54898).Intracellular,N-terminus.
- ExpressionofCACNA1G inratandmousecerebellumImmunohistochemicalstainingofmouse(A)andrat(B)cerebellumusing Anti-CACNA1G(CaV3.1)-ATTO-594 Antibody(#ACC-021-AR).A,B.CACNA1G staining(red)appearsinPurkinjeneurons(arrow)andinthemolecularlayer(Mol).NucleiwerestainedusingDAPIasthecounterstain(Blue).
- 1.Serrano,J.R.etal.(1999)J.Gen.Physiol.114,185.
- 2.Perez-Reyes,E.(2003)Physiol.Rev.83,117.
- 3.Wain,H.M.etal.(2002)NucleicAcidsRes.30,169.
- 4.Andreasen,D.etal.(2000)Am.J.Physiol.279,F997.
Voltage-dependentCa2+ channelsprovideapathwayforrapidinfluxofCa2+ intocells, whichplaysacrucialroleinbothelectricalandmetabolicsignaling.1
T-typecurrentsaretransducedviachannelproteinsencodedbythreegenesthat composeasubfamilywithintheCaVchannelfamily.2-3
TheactivityofT-typechannelscontributestoseveralknownphysiologicalandpathophysiological phenomenaincludingburstfiringinneurons,pacemakingactivityintheheartandsecretionfromendocrinetissues.2 TherearethreeclonedT-typechannelisoforms.
CACNA1G(CaV3.1)andCACNA1H(CaV3.2)arewidelydistributedwhereastheexpressionofCACNA1I(CaV3.3) isrestrictedtothecentralnervoussystem.2
CACNA1GandCACNA1H arealsoexpressedinthekidney,butlittleisknownabouttheirphysiologicalrolethere.
Anti-CACNA1G(CaV3.1)Antibody(#ACC-021)isahighlyspecificantibodydirectedagainstanepitopeoftheratCaV3.1channel.Theantibody canbeusedinwesternblot,immunocytochemistry,andimmunohistochemistryapplications.IthasbeendesignedtorecognizeCACNA1G fromhuman,rat,andmousesamples.
Anti-CACNA1G(CaV3.1)-ATTO-594Antibody(#ACC-021-AR)isdirectlylabeledwithATTO-594fluorescentdye.ATTOdyesarecharacterizedbystrongabsorption(highextinctioncoefficient),highfluorescencequantumyield,andhighphoto-stABIlity.TheATTO-594fluorescentlabelbelongstotheclassofRhodaminedyesandcanbeusedwithfluorescentequipmenttypicallyoptimizedtodetectTexasRedandAlexa-594.Anti-CACNA1G(CaV3.1)-ATTO-594Antibodyisidealforimmuno-colocalizationstudies.
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