BiologicalActivity
ReversIBLeinhibitorofregulatorofG-proteinsignaling(RGS)proteins.SelectiveamongstRGSproteins,withgreatestpotencyatRGS4.InhibitsGTPaseacceleratingproteinactivityofRGS4andblocksitsinteractionwithGαo.Retainsactivityunderreducingconditions.
TechnicalData
| M.Wt | 450.51 |
| Formula | C26H18N4O2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 620112-78-9 |
| PubChemID | 6057678 |
| InChIKey | VFSVKVQMZDJFQX-NBVRZTHBSA-N |
| Smiles | O=C1C(/C=C(C#N)/C3=NC(C=CC=C4)=C4S3)=C(OC5=CC(C)=CC=C5)N=C2N1C=CC=C2C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.25 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight450.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.22mL | 11.1mL | 22.2mL |
| 5mM | 0.44mL | 2.22mL | 4.44mL |
| 10mM | 0.22mL | 1.11mL | 2.22mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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