Tocris美元价/进货价 Tocris抗体,Tocris/Geldanamycin/1368/1/1 mg,白蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Geldanamycin/1368/1/1 mg

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Tocris

货号 /

1368/1

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4000-520-616

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Description:SelectiveHsp90inhibitor

ChemicalName:9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azABIcyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivelyinhibitsheatshockprotein90(Hsp90).BindstotheATPsiteofHsp90(K_d=1.2μM)andinhibitsitschaperoneactivity.Consequentlyinhibitsactivitiesofoncogenickinases(e.g.src,Raf),p53andsteroidreceptors.Demonstratesantiproliferativeeffectonbreastcancerstem-likecells.

TechnicalData

M.Wt	560.64
Formula	C₂₉H₄₀N₂O₉
Storage	Desiccateat-20°C
Purity	≥98%(HPLC)
CASNumber	30562-34-6
PubChemID	13017912
InChIKey	QTQAWLPCGQOSGP-PHLMVCJGSA-N
Smiles	O=C1C(OC)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	5.61	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight560.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.78mL	8.92mL	17.84mL
5mM	0.36mL	1.78mL	3.57mL
10mM	0.18mL	0.89mL	1.78mL
50mM	0.04mL	0.18mL	0.36mL

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