进口试剂Tocris直采 Tocris Bioscience型号参数规格,Tocris/Macbecin I/3061/1/1 mg,白蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Macbecin I/3061/1/1 mg

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Tocris

货号 /

3061/1

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4000-520-616

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Description:Hsp90inhibitor

ChemicalName:(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AnsamycinantibioticcompoundthatinhibitsHsp90activity(IC₅₀=2μM)bybindingtotheATP-bindingsite.Exhibitsantitumorandcytocidalactivities(IC₅₀~0.4μM)bycausingdegradationofkeyoncogenicclientproteinssuchasErbB2andcRaf1.Displayshigheraffinityandpotencythangeldanamycin(Cat.No.1368).

TechnicalData

M.Wt	558.67
Formula	C₃₀H₄₂N₂O₈
Storage	Desiccateat-20°C
CASNumber	73341-72-7
PubChemID	6436263
InChIKey	PLTGBUPHJAKFMA-HXUNTIRESA-N
Smiles	O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	SolubleinDMSO

Solubility

SolubleinDMSO

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight558.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.79mL	8.95mL	17.9mL
5mM	0.36mL	1.79mL	3.58mL
10mM	0.18mL	0.89mL	1.79mL
50mM	0.04mL	0.18mL	0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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