
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllSMAD4ispartoftheSMADfamilyofproteinsthatmediatesignaltransductionbytheTGF-beta/activin/BMP-2/4cytokinesuperfamilyfromreceptorSer/Thrproteinkinasesatthecellsurfacetothenucleus.SMAD4promotesthebindingoftheSMAD2/SMAD4/FAST-1complextoDNAandprovidesthefunctionofactivationrequiredforSMAD1orSMAD2tostimulatetranscriptionactsasatumorsuppressor.SMAD4isatargetmoleculeforfunctionalinactivationincervicalcancer.SMAD4isanimportantbioMarkerformalignanttransformationatakespartininducingapoptosisbymodulatingBcl-2/Baxbalance.
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