
Overview:
MGMTorO-6-methylguanine-DNAmethyltransferaseisthemajormutagenicandcarcinogeniclesioninDNAinducedbysimplealkylatingmutagens.ThemethylationoftheMGMTpromoteringliomasisausefulpredictoroftheresponsivenessofthetumorstoalkylatingagents(1).TheclinicaltrialsubstantiatesthepredictivevalueofO-6-methylguanine-DNAmethyltransferasepromotermethylationinglioblastomapatientstreatedwithtemozolomide(2).MethylationoftheMGMTpromoterintumorsisassociatedwithlongersurvivalinglioblastomapatients.
GeneAliases:
(None)
GenbankNumber:
BC000824
References:
1.Esteller,M.et.al:InactivationoftheDNA-repairgeneMGMTandtheclinicalresponseofgliomastoalkylatingagents.NewEng.J.Med.343:1350-1354,2000.2.Hegi,M.E.et.al:ClinicaltrialsubstantiatesthepredictivevalueofO-6-methylguanine-DNAmethyltransferasepromotermethylationinglioblastomapatientstreatedwithtemozolomide.Clin.CancerRes.10:1871-1874,2004.
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算上其他生物24种
大概是记不太清了

