
Overview:
PRMT5isaproteinargininemethyltransferaseandpartofa20SmethyltransferasecomplexthatmodifiesspecificargininestodimethylargininesinseveralspliceosomalSmproteins(1).ThismodificationtargetsSmproteinstothesurvivalofmotorneurons(SMN)complexforassemblyintosmallnuclearribonucleoproteincoreparticles.MEP50associateswithPRMT5inthe20SargininemethyltransferasecomplexinHeLacells(2).AntibodiesdirectedagainstMEP50canreducetheargininemethyltransferaseactivityoftheimmunopurifiedcomplextowardSmsubstrates.PRMT5-mediatedtranscriptionalrepressionofreportergeneisdependentonMEP50.
GeneAliases:
HRMT1L5;IBP72;JBP1;SKB1;SKB1Hs
GenbankNumber:
NM_006109
References:
1.Friesen,W.J.etal:AnovelWDrepeatproteincomponentofthemethylosomebindsSmproteins.J.Biol.Chem.277:8243-8247,2002.2.Furuno,K.etal:AssociationofPolycombgroupSUZ12withWD-repeatproteinMEP50thatbindstohistoneH2Aselectivelyinvitro.Biochem.Biophys.Res.Commun.345:1051-1058,2006.
ebiomall.com






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算上其他生物24种
大概是记不太清了

