
Overview:
SETMARorSETdomainandmarinertransposasefusiongeneisanonhomologousend-joiningrepairproteinthatregulatesgenomicintegrationofexogenousDNAbyopeningchromatinandfacilitatingjoiningofDNAends(1).SETMARhashistonemethyltransferaseactivityandmethylates"Lys-4"and"Lys-36"ofhistoneH3.SETMARalsohasDNAnickingactivityandmayplayaroleinDNArepair(2).HumanPso4formsastablecomplexwithSETMARthatregulatesMetnasefunctioninDNArepair.SETMARhassequence-specificDNA-bindingactivityandrecognizesthe19-mercoreofthe5"-terminalinvertedrepeats(TIRs)oftheHsmar1element.
GeneAliases:
METNASE
GenbankNumber:
BC011635
References:
1.Lee,S.-H.et.al:TheSETdomainproteinMetnasemediatesforeignDNAintegrationandlinksintegrationtononhomologousend-joiningrepair.Proc.Nat.Acad.Sci.102:18075-18080,2005.2.Liu,D.et.al:ThehumanSETMARproteinpreservesmostoftheactivitiesoftheancestralHsmar1transposase.Molec.Cell.Biol.27:1125-1132,2007.
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算上其他生物24种
大概是记不太清了

