
Overview:
SIRT2isamemberofthesirtuinfamilyofproteinswhicharehomologstotheyeastSir2protein.SirtuinfamilycontainasirtuincoredomainandaregroupedintofourclasseswithSIRT2beingamemberofclassI.InhibitionofSIRT2canleadtoneuroprotectionincellularandinvertebratemodelsofHuntington"sdisease(1).Huntington"sdiseaseischaracterizedbyincreasedsterolssynthesisinneuronalcellsandthisprocessisreversedbySIRT2inhibition.SIRT2candeacetylatelys40ofalpha-tubulinbothinvitroandinvivo(2).KnockdownofSIRT2viasmallinterferingRNAresultsintubulinhyperacetylation.
GeneAliases:
SIR2L,SIR2L2,Sirtuin2
GenbankNumber:
NM_030593
References:
1.Luthi-Carter,R.Etal:SIRT2inhibitionachievesneuroprotectionbydecreasingsterolbiosynthesis.ProcNatlAcadSciUSA.2010Apr27;107(17):7927-32.2.North,B.J.etal:ThehumanSir2ortholog,SIRT2,isanNAD(+)-dependenttubulindeacetylase.Molec.Cell11:437-444,2003.
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算上其他生物24种
大概是记不太清了

