
Overview:
SIRT4isamemberofthesirtuinfamilyofproteinswhicharehomologstotheyeastSir2protein.SirtuinfamilycontainasirtuincoredomainandaregroupedintofourclasseswithSIRT4beingamemberofclassIV.SIRT4lacksdeacetylaseactivitybuthasADP-ribosyltransferaseactivity(1).ImmunoprecipitationanalysisshowsthatSIRT4interactswiththemitochondrialenzymeglutamatedehydrogenase(GDH),andfunctionalanalysisshowthatSIRT4ADP-ribosylatesandinhibitsGDH(2).DownregulationofSIRT4byRNAinterferenceactivatesGDH,therebyupregulatinginsulinsecretioninresponsetoglucoseandaminoacids.
GeneAliases:
SIR2L4,MGC57437,MGC130046,MGC130047,sirtuin4
GenbankNumber:
NM_012240
References:
1.Frye,R.A.CharacterizationoffivehumanCDNAswithhomologytotheyeastSIR2gene:Sir2-likeproteins(sirtuins)metabolizeNADandmayhaveproteinADP-ribosyltransferaseactivity.Biochem.Biophys.Res.Commun.260:273-279,1999.2.Haigis,M.C.etal:SIRT4inhibitsglutamatedehydrogenaseandopposestheeffectsofcalorierestrictioninpancreaticbetacells.Cell126:941-954,2006.
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算上其他生物24种
大概是记不太清了

