
Overview:
Neuralprecursorcellexpressed,developmentallydown-regulated8(NEDD8)encodesaubiquitin-likeprotein(1).NEDD8canbeconjugatedtoproteinsviatheC-terminalGlybytheE2enzymeUbc12andE3ligasecomplextoaffectvarioussignalingmoleculessuchascullins,auxin,IRF3,MDM2,andp21(2).Onthecontrary,theNEDD8modifiedsubstratescanbereversedbydeneddylatingenzymessuchasCSN,NEDP1,UAP21,Ataxin3,PfUCH54,UCHL1andUCHL3(3).TheinhibitorofNEDD8suppressedthetumorgrowthinAMLcellsinxenograftassays(3).
GeneAliases:
NEDD-8
GenbankNumber:
NM_006156
References:
1.Kamitani,T,etal.CharacterizationofNEDD8,adevelopmentallydown-regulatedubiquitin-likeprotein.J.Biol.Chem.272,28557–28562(1997).2.SchmidtMHH,etal.UbiquitinandNEDD8:brothersinarms.SciSTKE.2006Nov21;2006(362).3.WatsonIR,etal.NEDD8pathwaysincancer,SineQuibusNon.CancerCell.2011Feb15;19(2):168-76.
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算上其他生物24种
大概是记不太清了

