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Novus/Recombinant Human TGF-beta 1 (Human Cell-expressed) Protein/25 ug/7754-BH-025
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4000-520-616
RecombinantHumanTGF-beta1(HumanCell-expressed)ProteinSummary
| DetailsofFunctionality | MeasuredbyitsABIlitytoinhibittheIL-4-dependentproliferationofHT‑2mouseT cells.Tsang, M.et al.(1995)Cytokine7:389.TheED50forthiseffectis0.04-0.2ng/mL. |
| Source | Humanembryonickidneycell,HEK293-derivedhumanTGF-beta1proteinAla279-Ser390 |
| Accession# | P01137 |
| N-terminalSequence | Ala279 |
| Structure/Form | Disulfide-linkedhomodimer |
| Protein/PeptideType | RecombinantProteins |
| Gene | TGFB1 |
| Purity | >95%,bySDS-PAGEunderreducingconditionsandvisualizedbysilverstain. |
| EndotoxinNote | <0.01 eu="" per="" 1="" μg="" of="" the="" protein="" by="" the="" lal=""> |
Applications/Dilutions
| TheoreticalMW | 12.8kDa(monomer).Disclaimernote:Theobservedmolecularweightoftheproteinmayvaryfromthelistedpredictedmolecularweightduetoposttranslationalmodifications,posttranslationcleavages,relativecharges,andotherexperimentalfactors. | |
| SDS-PAGE | 11kDa,reducingconditions | |
| Publications |
|
Packaging,Storage&Formulations
| Storage | Useamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.
|
| Buffer | Lyophilizedfroma0.2μmfilteredsolutioninAcetonitrileandTFAwithBSAasacarrierprotein.*1mgpacksize(01M)issuppliedasa0.2µmfilteredsolutioninAcetonitrileandTFAwithBSAasacarrierprotein. |
| Purity | >95%,bySDS-PAGEunderreducingconditionsandvisualizedbysilverstain. |
| ReconstitutionInstructions | Reconstituteat100μg/mLinsterile4mMHClcontainingatleast0.1%humanorbovineserumalbumin. |
Notes
ThisproductisproducedbyandshipsfromR&DSystems,Inc.,aBio-Technebrand.
AlternateNamesforRecombinantHumanTGF-beta1(HumanCell-expressed)Protein
- CEDLAP
- DPD1
- latency-associatedpeptide
- TGFbeta1
- TGFB
- TGFB1
- TGF-beta1protein
- TGFbeta1
- TGF-beta1
- TGFbeta
- TGF-beta-1
- transforminggrowthfactorbeta-1
- transforminggrowthfactor,beta1
Background
TGF‑beta1(transforminggrowthfactorbeta1)isoneofthreecloselyrelatedmammalianmembersofthelargeTGF‑betasuperfamilythatshareacharacteristiccystineknotstructure(1‑7).TGF‑beta1,‑2and‑3arehighlypleiotropiccytokinesthatareproposedtoactascellularswitchesthatregulateprocessessuchasimmunefunction,proliferationandepithelial‑mesenchymaltransition(1‑4).EachTGF‑betaisoformhassomenon‑redundantfunctions;forTGF‑beta1,micewithtargeteddeletionshowdefectsinhematopoiesisandendothelialdifferentiation,anddieofoverwhelminginflammation(2).HumanTGF‑beta1CDNAencodesa390aminoacid(aa)precursorthatcontainsa29aasignalpeptideanda361aaproprotein(8).Afurin-likeconvertaseprocessestheproproteintogenerateanN‑terminal249aalatency‑associatedpeptide(LAP)andaC‑terminal112aamatureTGF‑beta1(8,9).Disulfide-linkedhomodimersofLAPandTGF‑beta1remainnon‑covalentlyassociatedaftersecretion,formingthesmalllatentTGF‑beta1complex(8‑10).CovalentlinkageofLAPtooneofthreelatentTGF‑betabindingproteins(LTBPs)createsalargelatentcomplexthatmayinteractwiththeextracellularmatrix(9,10).TGF‑betaisactivatedfromlatencybypathwaysthatincludeactionsoftheproteaseplasmin,matrixmetalloproteases,thrombospondin1andasubsetofintegrins(10).MaturehumanTGF‑beta1shares100%aaidentitywithpig,dogandcowTGF‑beta1,and99%aaidentitywithmouse,ratandhorseTGF‑beta1.Itdemonstratescross‑speciesactivity(1).TGF‑beta1signalingbeginswithhigh‑affinitybindingtoatypeIIser/thrkinasereceptortermedTGF‑betaRII.Thisreceptorthenphosphorylatesandactivatesasecondser/thrkinasereceptor,TGF‑betaRI(alsocalledactivinreceptor‑likekinase(ALK)‑5),oralternatively,ALK‑1.ThiscomplexphosphorylatesandactivatesSmadproteinsthatregulatetranscription(3,11,12).Contributionsoftheaccessoryreceptorsbetaglycan(alsoknownasTGF‑betaRIII)andendoglin,oruseofSmad-independentsignalingpathways,allowfordisparateactionsobservedinresponsetoTGF‑betaindifferentcontexts(11).
- Derynck,R.andK.Miyazono(2008)ColdSpringHarborLaboratoryPressp.29.
- Dunker,N.andK.Krieglstein(2000)Eur.J.Biochem.267:6982.
- Wahl,S.M.(2006)Immunol.Rev.213:213.
- Chang,H.etal.(2002)Endocr.Rev.23:787.
- Lin,J.S.etal.(2006)Reproduction132:179.
- Hinck,A.P.etal.(1996)Biochemistry35:8517.
- Mittl,P.R.E.etal.(1996)ProteinSci.5:1261.
- Derynck,R.etal.(1985)Nature316:701.
- Miyazono,K.etal.(1988)J.Biol.Chem.263:6407.
- Oklu,R.andR.Hesketh(2000)Biochem.J.352:601.
- deCaestecker,M.etal.(2004)CytokineGrowthFactorRev.15:1.
- Zuniga,J.E.etal.(2005)J.Mol.Biol.354:1052.
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请教，天然菌种发酵的蛋白和重组技术发酵的蛋白在质量检测指标上有何区别？谢谢！
抗体常见问题与解答_蛋白123
tjzbyw2021-07-20
我想做个目的蛋白的单抗，通过基因克隆、表达、纯化来得到目的蛋白，但是因为用的是原核表达系统，缺少翻译后的正常修饰，所以肯定与天然蛋白有区别，这样的话，作出来的单抗就不一定能够识别组织中的天然蛋白了，有什么方法可以减少他们的差异？也就是尽量让单抗可以识别天然蛋白。谢谢！
gleason分级_123
隐幽羽2018-02-04
如题，最好有详解
牛乳糖合成酶(LS)ELISA试剂盒质量保证_123
2018-02-06
氨基酸
天然蛋白疏水层析问题?_问答详情_其它天然蛋白_天然蛋白_蛋白类...123
zysshine2010-05-28
想提纯一种天然蛋白,目前实验室没有这个条件,请问国内有哪些渠道...123
ohoooooo2017-10-24
本人目前需从电鳗放电器官中提取乙酰胆碱受体蛋白，提纯需要的步骤和电鳗器官都可以提供，有没有提供外包提纯服务的公司或者实验室。
天然蛋白质中不存在的氨基酸是()A.半胱氨酸B.瓜氨酸C.蛋氨酸D.羟...123
yzhuzhuq1392011-08-31
构成天然蛋白质的氨基酸有几种 123
2018-02-04
人体能产生20种
算上其他生物24种
大概是记不太清了
算上其他生物24种
大概是记不太清了
【求助】10株单抗没一株能与天然蛋白反应 免疫学讨论版论坛123
luliangshun2007-01-31
小弟用E.coli表达的一蛋白(一天然毒素的N段)制备了11株单抗,但没有一株能中和天然蛋白,这可急死我了.再拖下去就不能毕业了.导师天天催我建立诊断方法呢.大家给我出出主意!
Science子刊新研究找到治疗致命脑癌的关键靶点 分析行业新闻123
sunyongjun2021-07-23
http://www.medicalnewstoday.com/medicalnews.php?newsid=58498
NaturalProteinStopsDeadlyHumanBrainCancerInMice
ScientistsfromJohnsHopkinsandfromtheUniversityofMilanhaveeffectivelyproventhattheycaninhibitlethalhumanbraincancersinmiceusingaproteinthatselectivelyinducespositivechangesintheactivityofcellsthatbehavelikecancerstemcells.ThereportispublishedinNature.
Themostcommontypeofbraincancer-glioblastoma-ismarkedbythepresenceofthesestem-cell-likebraincells,which,insteadoftriggeringthereplacementofdamagedcells,formcancertissue.Stemcells,unlikeallothercellsinthebody,arecapableofformingalmostanykindofcellwhentheright"signals"triggertheirdevelopment.
Fortheirtreatmentexperiment,theresearchersreliedonaclassofproteins,bonemorphogenicproteins,thatcauseneuralstem-cell-likeclusterstolosetheirstemcellproperties,whichinturnstopstheirABIlitytodivide.
Firsttheypretreatedhumanglioblastomacellswithbonemorphogenicprotein4(BMP4),theninjectedthesetreatedcellsintomousebrains.Inmiceinjectedwithcellsthatwerenotpretreated,large,invasivecancersgrew.InthemicewithBMP4-treatedcells,nocancersgrewatall.Threetofourmonthsafterinjection,allmicethatgotuntreatedcellsdied,andnearlyallmicewithBMP4-treatedcellswerealive.
Next,thescientistsdeliveredslow-releaseBMP4-containing"beads"directlyintomousebrainswithimplantedglioblastomacells.Micethatgotemptybeadsdevelopedlargemalignanttumorsanddied.MicewithBMP4beadssurvivedmuchlonger,and80percentsurvivedfourmonthsaftercancercellimplants.
"OurideaistotreatpatientswithBMP4orsomethinglikeitrightaftersurgerytoremoveglioblastomainhopesofpreventingtheregrowthofthecancerandimprovingsurvivaltime,"saysAlessandroOlivi,M.D.,directoroftheDivisionofNeurosurgicalOncologyatHopkinsandacontributortothestudy.
OlivisaysclinicalstudiesusingBMP4couldbeginwithinayearand,ifsuccessful,drugtherapiescouldbeavailabletothepublicwithinthreetofouryears.
"ThiswasproofoftheideathatBMPscouldstopglioblastomabydepletingthestem-cell-likepopulationthatfeedsit,"saysHenryBrem,M.D.,chairmanoftheDepartmentofNeurosurgeryatHopkinsandacollaboratorinthestudy."Thisopensexcitingdoorstofutureresearchintotreatmentsandtherapiesforsuchadevastatingdisease."
NaturalProteinStopsDeadlyHumanBrainCancerInMice
ScientistsfromJohnsHopkinsandfromtheUniversityofMilanhaveeffectivelyproventhattheycaninhibitlethalhumanbraincancersinmiceusingaproteinthatselectivelyinducespositivechangesintheactivityofcellsthatbehavelikecancerstemcells.ThereportispublishedinNature.
Themostcommontypeofbraincancer-glioblastoma-ismarkedbythepresenceofthesestem-cell-likebraincells,which,insteadoftriggeringthereplacementofdamagedcells,formcancertissue.Stemcells,unlikeallothercellsinthebody,arecapableofformingalmostanykindofcellwhentheright"signals"triggertheirdevelopment.
Fortheirtreatmentexperiment,theresearchersreliedonaclassofproteins,bonemorphogenicproteins,thatcauseneuralstem-cell-likeclusterstolosetheirstemcellproperties,whichinturnstopstheirABIlitytodivide.
Firsttheypretreatedhumanglioblastomacellswithbonemorphogenicprotein4(BMP4),theninjectedthesetreatedcellsintomousebrains.Inmiceinjectedwithcellsthatwerenotpretreated,large,invasivecancersgrew.InthemicewithBMP4-treatedcells,nocancersgrewatall.Threetofourmonthsafterinjection,allmicethatgotuntreatedcellsdied,andnearlyallmicewithBMP4-treatedcellswerealive.
Next,thescientistsdeliveredslow-releaseBMP4-containing"beads"directlyintomousebrainswithimplantedglioblastomacells.Micethatgotemptybeadsdevelopedlargemalignanttumorsanddied.MicewithBMP4beadssurvivedmuchlonger,and80percentsurvivedfourmonthsaftercancercellimplants.
"OurideaistotreatpatientswithBMP4orsomethinglikeitrightaftersurgerytoremoveglioblastomainhopesofpreventingtheregrowthofthecancerandimprovingsurvivaltime,"saysAlessandroOlivi,M.D.,directoroftheDivisionofNeurosurgicalOncologyatHopkinsandacontributortothestudy.
OlivisaysclinicalstudiesusingBMP4couldbeginwithinayearand,ifsuccessful,drugtherapiescouldbeavailabletothepublicwithinthreetofouryears.
"ThiswasproofoftheideathatBMPscouldstopglioblastomabydepletingthestem-cell-likepopulationthatfeedsit,"saysHenryBrem,M.D.,chairmanoftheDepartmentofNeurosurgeryatHopkinsandacollaboratorinthestudy."Thisopensexcitingdoorstofutureresearchintotreatmentsandtherapiesforsuchadevastatingdisease."
天然蛋白质的组成元素 微思作业本123
小懒0无罪2018-02-03
常见的都是天然蛋白质，人工合成的蛋白质也是要遵从自然界的规律的，元素不是说添加就添加的，人工合成的蛋白质也离不开天然蛋白质的这些组成元素。蛋白质主要是由C（碳）、H（氢）、O（氧）、N（氮）组成，一般蛋白质可能还会含有P、S、Fe（铁）、Zn（锌）、Cu（铜）、B（硼）、Mn(锰)、I（碘）、Mo（钼）等 。
高级生物化学问答题123
yjgao2021-07-21
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