商品信息
联系客服
郑重提醒：
无质量问题不接受退换货，下单前请仔细核对信息。
下单后请及时联系客服核对商品价格，订单生效后再付款。
Novus/Recombinant Human TGF-beta 1 (Human Cell-expressed) Protein/25 ug/7754-BH-025
免费咨询热线
4000-520-616
RecombinantHumanTGF-beta1(HumanCell-expressed)ProteinSummary
| DetailsofFunctionality | MeasuredbyitsABIlitytoinhibittheIL-4-dependentproliferationofHT‑2mouseT cells.Tsang, M.et al.(1995)Cytokine7:389.TheED50forthiseffectis0.04-0.2ng/mL. |
| Source | Humanembryonickidneycell,HEK293-derivedhumanTGF-beta1proteinAla279-Ser390 |
| Accession# | P01137 |
| N-terminalSequence | Ala279 |
| Structure/Form | Disulfide-linkedhomodimer |
| Protein/PeptideType | RecombinantProteins |
| Gene | TGFB1 |
| Purity | >95%,bySDS-PAGEunderreducingconditionsandvisualizedbysilverstain. |
| EndotoxinNote | <0.01 eu="" per="" 1="" μg="" of="" the="" protein="" by="" the="" lal=""> |
Applications/Dilutions
| TheoreticalMW | 12.8kDa(monomer).Disclaimernote:Theobservedmolecularweightoftheproteinmayvaryfromthelistedpredictedmolecularweightduetoposttranslationalmodifications,posttranslationcleavages,relativecharges,andotherexperimentalfactors. | |
| SDS-PAGE | 11kDa,reducingconditions | |
| Publications |
|
Packaging,Storage&Formulations
| Storage | Useamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.
|
| Buffer | Lyophilizedfroma0.2μmfilteredsolutioninAcetonitrileandTFAwithBSAasacarrierprotein.*1mgpacksize(01M)issuppliedasa0.2µmfilteredsolutioninAcetonitrileandTFAwithBSAasacarrierprotein. |
| Purity | >95%,bySDS-PAGEunderreducingconditionsandvisualizedbysilverstain. |
| ReconstitutionInstructions | Reconstituteat100μg/mLinsterile4mMHClcontainingatleast0.1%humanorbovineserumalbumin. |
Notes
ThisproductisproducedbyandshipsfromR&DSystems,Inc.,aBio-Technebrand.
AlternateNamesforRecombinantHumanTGF-beta1(HumanCell-expressed)Protein
- CEDLAP
- DPD1
- latency-associatedpeptide
- TGFbeta1
- TGFB
- TGFB1
- TGF-beta1protein
- TGFbeta1
- TGF-beta1
- TGFbeta
- TGF-beta-1
- transforminggrowthfactorbeta-1
- transforminggrowthfactor,beta1
Background
TGF‑beta1(transforminggrowthfactorbeta1)isoneofthreecloselyrelatedmammalianmembersofthelargeTGF‑betasuperfamilythatshareacharacteristiccystineknotstructure(1‑7).TGF‑beta1,‑2and‑3arehighlypleiotropiccytokinesthatareproposedtoactascellularswitchesthatregulateprocessessuchasimmunefunction,proliferationandepithelial‑mesenchymaltransition(1‑4).EachTGF‑betaisoformhassomenon‑redundantfunctions;forTGF‑beta1,micewithtargeteddeletionshowdefectsinhematopoiesisandendothelialdifferentiation,anddieofoverwhelminginflammation(2).HumanTGF‑beta1CDNAencodesa390aminoacid(aa)precursorthatcontainsa29aasignalpeptideanda361aaproprotein(8).Afurin-likeconvertaseprocessestheproproteintogenerateanN‑terminal249aalatency‑associatedpeptide(LAP)andaC‑terminal112aamatureTGF‑beta1(8,9).Disulfide-linkedhomodimersofLAPandTGF‑beta1remainnon‑covalentlyassociatedaftersecretion,formingthesmalllatentTGF‑beta1complex(8‑10).CovalentlinkageofLAPtooneofthreelatentTGF‑betabindingproteins(LTBPs)createsalargelatentcomplexthatmayinteractwiththeextracellularmatrix(9,10).TGF‑betaisactivatedfromlatencybypathwaysthatincludeactionsoftheproteaseplasmin,matrixmetalloproteases,thrombospondin1andasubsetofintegrins(10).MaturehumanTGF‑beta1shares100%aaidentitywithpig,dogandcowTGF‑beta1,and99%aaidentitywithmouse,ratandhorseTGF‑beta1.Itdemonstratescross‑speciesactivity(1).TGF‑beta1signalingbeginswithhigh‑affinitybindingtoatypeIIser/thrkinasereceptortermedTGF‑betaRII.Thisreceptorthenphosphorylatesandactivatesasecondser/thrkinasereceptor,TGF‑betaRI(alsocalledactivinreceptor‑likekinase(ALK)‑5),oralternatively,ALK‑1.ThiscomplexphosphorylatesandactivatesSmadproteinsthatregulatetranscription(3,11,12).Contributionsoftheaccessoryreceptorsbetaglycan(alsoknownasTGF‑betaRIII)andendoglin,oruseofSmad-independentsignalingpathways,allowfordisparateactionsobservedinresponsetoTGF‑betaindifferentcontexts(11).
- Derynck,R.andK.Miyazono(2008)ColdSpringHarborLaboratoryPressp.29.
- Dunker,N.andK.Krieglstein(2000)Eur.J.Biochem.267:6982.
- Wahl,S.M.(2006)Immunol.Rev.213:213.
- Chang,H.etal.(2002)Endocr.Rev.23:787.
- Lin,J.S.etal.(2006)Reproduction132:179.
- Hinck,A.P.etal.(1996)Biochemistry35:8517.
- Mittl,P.R.E.etal.(1996)ProteinSci.5:1261.
- Derynck,R.etal.(1985)Nature316:701.
- Miyazono,K.etal.(1988)J.Biol.Chem.263:6407.
- Oklu,R.andR.Hesketh(2000)Biochem.J.352:601.
- deCaestecker,M.etal.(2004)CytokineGrowthFactorRev.15:1.
- Zuniga,J.E.etal.(2005)J.Mol.Biol.354:1052.
CustomersWhoViewedThisItemAlsoViewed...
TNF-alpha[Unconjugated]
210-TA
(24Reviews)
(607Publications)
Species:Hu
IL-6[Unconjugated]
7270-IL/CF
![IL-6 [Unconjugated]](images/novusbio/novus_guarantee.png "IL-6 [Unconjugated]")
Species:Hu
Smad2/3Antibody[Unconjugated]
AF3797
(2Reviews)
(12Publications)
Species:Hu,Mu
Applications:WB,SimpleWestern,ChIP,ICC
Smad3Antibody
NB100-56479
![Western Blot: Smad3 Antibody [NB100-56479] - Analysis in human fibroblast and HeLa whole cell lysates. Untreated lysates show aband around 55 Kda. 1:1000 dilution, 1 hour blocking in milk 5%. Image from a verified customer review.](http://images.novusbio.com/images2/Smad3-Antibody-Western-Blot-NB100-56479-img0008.jpg)
![Immunocytochemistry/Immunofluorescence: Smad3 Antibody [NB100-56479] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.5% Triton-X100. The cells were incubated with anti-Smad3 at 10 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.](http://images.novusbio.com/images2/Smad3-Antibody-Immunocytochemistry-Immunofluorescence-NB100-56479-img0006.jpg)
![Immunohistochemistry-Paraffin: Smad3 Antibody [NB100-56479] - Human liver tissue probed with SMAD3 antibody (bottom left, right) and isotype control antibody (top left) at 10 ug/ml.](http://images.novusbio.com/images2/Smad3-Antibody-Immunohistochemistry-Paraffin-NB100-56479-img0004.jpg)
(1Review)
(2Publications)
Species:Hu,Mu,Rt,Po,Bv,Ca,Pm
Applications:WB,ICC/IF,IHC,IHC-P
CTGF/CCN2Antibody
NB100-724
![Immunocytochemistry/Immunofluorescence: CTGF/CCN2 Antibody [NB100-724] - CTGF antibody was tested in U2OS cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).](http://images.novusbio.com/images2/CTGF-CCN2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-724-img0004.jpg)
(4Publications)
Species:Hu,Mu,Rt
Applications:WB,ICC/IF,IHC,IHC-P
FibronectinAntibody
NBP1-91258
![Western Blot: Fibronectin Antibody [NBP1-91258] - Analysis of Fibronectin in NIH 3T3 cell lysate.](http://images.novusbio.com/images/Fibronectin-Antibody-Western-Blot-NBP1-91258-img0004.jpg)
![Immunocytochemistry/Immunofluorescence: Fibronectin Antibody [NBP1-91258] - NIH-3T3 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton X-100. The cells were incubated with anti-Fibronectin at 2 ug/mL overnight at 4C and detected with an anti-rabbit DyLight 488 (Green) at 1:500. Alpha tubulin (DM1A) NB100-690 was used as a co-stain at 1:1000 and detected with an anti-mouse DyLight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.](http://images.novusbio.com/images2/Fibronectin-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-91258-img0012.jpg)
![Immunohistochemistry-Frozen: Fibronectin Antibody [NBP1-91258] - Analysis in a 6 month old Alport mouse kidney. Image from a verified customer review.](http://images.novusbio.com/images2/Fibronectin-Antibody-Immunohistochemistry-Frozen-NBP1-91258-img0019.jpg)
(9Reviews)
(23Publications)
Species:Hu,Mu,Rt,Po,Bv,Ca,Eq,Fe
Applications:WB,SimpleWestern,ICC/IF,IHC,IHC-Fr,IHC-P
FGFbasic/FGF2/bFGF[Unco
233-FB
(13Reviews)
(340Publications)
Species:Hu
LAP3Antibody
NBP1-82847
![Western Blot: LAP3 Antibody [NBP1-82847] - Analysis using Anti-LAP3 antibody NBP1-82847 (A) shows similar pattern to independent antibody NBP1-82848 (B).](http://images.novusbio.com/images2/LAP3-Antibody-Western-Blot-NBP1-82847-img0012.jpg)
![Immunocytochemistry/Immunofluorescence: LAP3 Antibody [NBP1-82847] - Staining of human cell line U-251 MG shows localization to nucleoplasm, cytosol & midbody.](http://images.novusbio.com/images2/LAP3-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-82847-img0006.jpg)
![Immunohistochemistry-Paraffin: LAP3 Antibody [NBP1-82847] - Staining of human kidney.](http://images.novusbio.com/images2/LAP3 Antibody-Immunohistochemistry-Paraffin-NBP1-82847-img0014.jpg)
Species:Hu
Applications:WB,ICC/IF,IHC,IHC-P
TGF-betaRI/ALK-5Antibody(141231)[Un...
MAB5871
(1Review)
(5Publications)
Species:Hu,Mu
Applications:WB
EGF[Unconjugated]
236-EG
(14Reviews)
(413Publications)
Species:Hu
Smad4Antibody(SP05-05)
NBP2-67372
![Western Blot: Smad4 Antibody (SP05-05) [NBP2-67372] - Analysis of Smad4 on PC-12 cells lysates using anti-Smad4 antibody at 1/1,000 dilution.](http://images.novusbio.com/images2/Smad4 Antibody (SP05-05)-Western Blot-NBP2-67372-img0009.jpg)
![Immunocytochemistry/Immunofluorescence: Smad4 Antibody (SP05-05) [NBP2-67372] - Staining Smad4 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.](http://images.novusbio.com/images2/Smad4-Antibody-(SP05-05)-Immunocytochemistry-Immunofluorescence-NBP2-67372-img0004.jpg)
![Immunohistochemistry-Paraffin: Smad4 Antibody (SP05-05) [NBP2-67372] - Analysis of paraffin-embedded mouse colon tissue using anti-Smad4 antibody. Counter stained with hematoxylin.](http://images.novusbio.com/images2/Smad4-Antibody-(SP05-05)-Immunohistochemistry-Paraffin-NBP2-67372-img0008.jpg)
Species:Hu,Mu,Rt
Applications:WB,Flow,ICC/IF,IHC,IHC-P
TGF-beta1[Unconjugated]
7754-BH/CF
(4Publications)
Species:Hu
ERK2Antibody(SZ25-01)
NBP2-67360
![Western Blot: ERK2 Antibody (SZ25-01) [NBP2-67360] - Analysis of ERK2 on different lysates using anti-ERK2 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: PC-12](http://images.novusbio.com/images2/ERK2 Antibody (SZ25-01)-Western Blot-NBP2-67360-img0008.jpg)
![Immunocytochemistry/Immunofluorescence: ERK2 Antibody (SZ25-01) [NBP2-67360] - Staining ERK2 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.](http://images.novusbio.com/images2/ERK2-Antibody-(SZ25-01)-Immunocytochemistry-Immunofluorescence-NBP2-67360-img0004.jpg)
![Immunohistochemistry-Paraffin: ERK2 Antibody (SZ25-01) [NBP2-67360] - Analysis of paraffin-embedded mouse stomach tissue using anti-ERK2 antibody. Counter stained with hematoxylin.](http://images.novusbio.com/images2/ERK2-Antibody-(SZ25-01)-Immunohistochemistry-Paraffin-NBP2-67360-img0007.jpg)
Species:Hu,Mu,Rt
Applications:WB,Flow,ICC/IF,IHC,IHC-P,IP
IL-4
6507-IL/CF
(3Publications)
Species:Hu
Smad7Antibody(293039)[Unconjugate
MAB2029
(1Review)
(23Publications)
Species:Hu,Mu,Rt
Applications:WB,SimpleWestern,IHC
RecombinantHumanTGF-beta1(HumanCel...
7754-BH
Species:Hu
Applications:Bioactivity
蚂蚁淘电商平台
ebiomall.com
ebiomall.com
公司简介
蚂蚁淘（www.ebiomall.cn）是中国大陆目前唯一的生物医疗科研用品B2B跨境交易平台，
该平台由多位经验丰富的生物人和IT人负责运营。蚂蚁淘B2B模式是指客户有采购意向后在蚂蚁
淘搜索全球供应信息，找到合适的产品后在蚂蚁淘下单，然后蚂蚁淘的海外买手进行跨境采购、
运输到中国口岸，最后由蚂蚁淘国内团队报关运输给客户...
蚂蚁淘承诺
正品保证： 全球直采 在线追溯
蚂蚁淘所有产品都是自运营的，我们已经跟国外多家厂方建立品牌推广合作关系, 获得对方的支持和授权； 同时客户可以通过订单详情查看到货物从厂方至客户的所有流程， 确保货物的来源； 正规报关，提供13%增值税发票。
及时交付： 限时必达 畅选无忧
蚂蚁淘的运营团队都是有着多年经验的成员，他们熟悉海外采购、仓储物流、报关等环节； 同时通过在线的流程监控，蚂蚁淘的进口速度比传统企业提高了50%以上， 部分产品甚至能做到7-10天到货，即蚂蚁淘的“时必达”服务。
轻松采购： 在线下单 简单省事
蚂蚁淘的价格是真实透明的，并且具有很大的价格优势，不需要繁杂的询价比价； 报价单与合同可以直接在线生成或打印；就像在京东购物一样， 您的鼠标点击几 次即完成在蚂蚁淘的采购，订单详情会告诉您所有进程。
售后申请： 耐心讲解 优质服务
蚂蚁淘提供的产品在使用过程中如因产品质量问题有售后需求时， 您可通过我的订单提交您的“申请售后”， 蚂蚁淘产品顾问会第一时间为您处理， 在售后服务过程中如遇到问题也可致电蚂蚁淘客服热线：4000-520-616。
2021-07-23
上海沪震实业有限公司在发布的FABP8重组蛋白供应信息，浏览与FABP8重组蛋白相关的产品或在搜索更多与FABP8重组蛋白相关的内容。 查看更多
>
2018-12-26
Phosphoamino acid analysis:Mark Kamps"s method 1. Label your protein with 32Pi. Then subject the protein to SDS polyacrylamide gel electrophoresis and transfer 查看更多
>
2021-08-03
上海钰博生物科技有限公司在发布的细胞分裂周期因子25B(CDC25B)重组蛋白供应信息，浏览与细胞分裂周期因子25B(CDC25B)重组蛋白相关的产品或在搜索更多与细胞分裂周期因子25B(CDC25B)重组蛋白相关的内容。 查看更多
>
2018-03-20
上海钰博生物科技有限公司在发布的FK506结合蛋白5(FKBP5)重组蛋白供应信息，浏览与FK506结合蛋白5(FKBP5)重组蛋白相关的产品或在搜索更多与FK506结合蛋白5(FKBP5)重组蛋白相关的内容。 查看更多
>
2021-07-24
艾美捷科技有限公司在发布的TMEM184B人源全长重组蛋白(P01) | TMEM184B (Human) Recombinant Protein (P01)供应信息，浏览与TMEM184B人源全长重组蛋白(P01) | TMEM184B (Human) Recombinant Protein (P01)相关的产品或在搜索更多与TMEM184B人源全长重组蛋白(P01) | TMEM184B (Human) Recombinant Protein (P01)相关的内容。 查看更多
>
2021-08-06
北京孚博生物科技有限公司在发布的小鼠Ankrd33重组蛋白供应信息，浏览与小鼠Ankrd33重组蛋白相关的产品或在搜索更多与小鼠Ankrd33重组蛋白相关的内容。 查看更多
>
2021-08-20
上海信裕生物科技有限公司在发布的融合蛋白(FUS)重组蛋白 供应信息，浏览与融合蛋白(FUS)重组蛋白 相关的产品或在搜索更多与融合蛋白(FUS)重组蛋白 相关的内容。 查看更多
>
2018-03-20
上海柯雷生物科技有限公司在发布的R-脊椎蛋白1(RSPO1)重组蛋白供应信息，浏览与R-脊椎蛋白1(RSPO1)重组蛋白相关的产品或在搜索更多与R-脊椎蛋白1(RSPO1)重组蛋白相关的内容。 查看更多
>
2019-01-19
服务名称：天然蛋白的序列分析测定——技术服务 查看更多
>
2021-07-28
上海泽叶生物科技有限公司在发布的精神分裂症破坏蛋白1(DISC1)重组蛋白供应信息，浏览与精神分裂症破坏蛋白1(DISC1)重组蛋白相关的产品或在搜索更多与精神分裂症破坏蛋白1(DISC1)重组蛋白相关的内容。 查看更多
>
常见问题
蚂蚁淘所售产品均为正品吗？
蚂蚁淘的创始人兼CEO是钟定松先生，具有十年的从业经验，在业界享有良好的口碑；
Ebiomall是跨境直采平台，我们直接从厂家采购，自己的团队负责国际物流和清关，中间没有第三方，蚂蚁淘承诺所售产品仅为正品，假一罚十。
下单后可以修改订单吗？
未确认状态的订单可以修改，打开“订单详情”页面，点击右上角的“修改订单”即可，若已审核确定，则订单无法修改。
商品几天可以发货？
现货产品付款审核后即可发货,大部分期货产品在3周左右即可到货,提供时必达服务的产品订单审核十天内即可发货。
订单如何取消？
如订单处于未确定状态，进入“我的订单"页面，找到要取消的订单，点击“取消订单”按钮。
可以开发票吗？
本网站所售商品都是正规清关，均开具13%正规发票，发票金额含配送费金额，另有说明的除外。
如何联系商家？
蚂蚁淘任何页面都有在线咨询功能，点击“联系客服”、“咨询”或“在线咨询”按钮，均可咨询蚂蚁淘在线客服人员，
或拨打4000-520-616，除此之外客户可在 联系我们页面找到更多的联系方式。
收到的商品少了/发错了怎么办？
同个订单购买多个商品可能会分为一个以上包裹发出，可能不会同时送达，建议查看订单详情是否是部分发货状态；如未收到，可联系在线客服或者致电4000-520-616。
退换货/维修需要多长时间？
一般情况下，退货处理周期为客户收到产品一个月内（以快递公司显示签收时间为准），包装规格、数量、品种不符，外观毁损、短缺或缺陷，请在收到货24小时内申请退换货；特殊商品以合同条款为准。
商品咨询
gleason分级_123
隐幽羽2018-02-04
如题，最好有详解
牛乳糖合成酶(LS)ELISA试剂盒质量保证_123
2018-02-06
氨基酸
Science子刊新研究找到治疗致命脑癌的关键靶点 分析行业新闻123
sunyongjun2021-07-23
http://www.medicalnewstoday.com/medicalnews.php?newsid=58498
NaturalProteinStopsDeadlyHumanBrainCancerInMice
ScientistsfromJohnsHopkinsandfromtheUniversityofMilanhaveeffectivelyproventhattheycaninhibitlethalhumanbraincancersinmiceusingaproteinthatselectivelyinducespositivechangesintheactivityofcellsthatbehavelikecancerstemcells.ThereportispublishedinNature.
Themostcommontypeofbraincancer-glioblastoma-ismarkedbythepresenceofthesestem-cell-likebraincells,which,insteadoftriggeringthereplacementofdamagedcells,formcancertissue.Stemcells,unlikeallothercellsinthebody,arecapableofformingalmostanykindofcellwhentheright"signals"triggertheirdevelopment.
Fortheirtreatmentexperiment,theresearchersreliedonaclassofproteins,bonemorphogenicproteins,thatcauseneuralstem-cell-likeclusterstolosetheirstemcellproperties,whichinturnstopstheirABIlitytodivide.
Firsttheypretreatedhumanglioblastomacellswithbonemorphogenicprotein4(BMP4),theninjectedthesetreatedcellsintomousebrains.Inmiceinjectedwithcellsthatwerenotpretreated,large,invasivecancersgrew.InthemicewithBMP4-treatedcells,nocancersgrewatall.Threetofourmonthsafterinjection,allmicethatgotuntreatedcellsdied,andnearlyallmicewithBMP4-treatedcellswerealive.
Next,thescientistsdeliveredslow-releaseBMP4-containing"beads"directlyintomousebrainswithimplantedglioblastomacells.Micethatgotemptybeadsdevelopedlargemalignanttumorsanddied.MicewithBMP4beadssurvivedmuchlonger,and80percentsurvivedfourmonthsaftercancercellimplants.
"OurideaistotreatpatientswithBMP4orsomethinglikeitrightaftersurgerytoremoveglioblastomainhopesofpreventingtheregrowthofthecancerandimprovingsurvivaltime,"saysAlessandroOlivi,M.D.,directoroftheDivisionofNeurosurgicalOncologyatHopkinsandacontributortothestudy.
OlivisaysclinicalstudiesusingBMP4couldbeginwithinayearand,ifsuccessful,drugtherapiescouldbeavailabletothepublicwithinthreetofouryears.
"ThiswasproofoftheideathatBMPscouldstopglioblastomabydepletingthestem-cell-likepopulationthatfeedsit,"saysHenryBrem,M.D.,chairmanoftheDepartmentofNeurosurgeryatHopkinsandacollaboratorinthestudy."Thisopensexcitingdoorstofutureresearchintotreatmentsandtherapiesforsuchadevastatingdisease."
NaturalProteinStopsDeadlyHumanBrainCancerInMice
ScientistsfromJohnsHopkinsandfromtheUniversityofMilanhaveeffectivelyproventhattheycaninhibitlethalhumanbraincancersinmiceusingaproteinthatselectivelyinducespositivechangesintheactivityofcellsthatbehavelikecancerstemcells.ThereportispublishedinNature.
Themostcommontypeofbraincancer-glioblastoma-ismarkedbythepresenceofthesestem-cell-likebraincells,which,insteadoftriggeringthereplacementofdamagedcells,formcancertissue.Stemcells,unlikeallothercellsinthebody,arecapableofformingalmostanykindofcellwhentheright"signals"triggertheirdevelopment.
Fortheirtreatmentexperiment,theresearchersreliedonaclassofproteins,bonemorphogenicproteins,thatcauseneuralstem-cell-likeclusterstolosetheirstemcellproperties,whichinturnstopstheirABIlitytodivide.
Firsttheypretreatedhumanglioblastomacellswithbonemorphogenicprotein4(BMP4),theninjectedthesetreatedcellsintomousebrains.Inmiceinjectedwithcellsthatwerenotpretreated,large,invasivecancersgrew.InthemicewithBMP4-treatedcells,nocancersgrewatall.Threetofourmonthsafterinjection,allmicethatgotuntreatedcellsdied,andnearlyallmicewithBMP4-treatedcellswerealive.
Next,thescientistsdeliveredslow-releaseBMP4-containing"beads"directlyintomousebrainswithimplantedglioblastomacells.Micethatgotemptybeadsdevelopedlargemalignanttumorsanddied.MicewithBMP4beadssurvivedmuchlonger,and80percentsurvivedfourmonthsaftercancercellimplants.
"OurideaistotreatpatientswithBMP4orsomethinglikeitrightaftersurgerytoremoveglioblastomainhopesofpreventingtheregrowthofthecancerandimprovingsurvivaltime,"saysAlessandroOlivi,M.D.,directoroftheDivisionofNeurosurgicalOncologyatHopkinsandacontributortothestudy.
OlivisaysclinicalstudiesusingBMP4couldbeginwithinayearand,ifsuccessful,drugtherapiescouldbeavailabletothepublicwithinthreetofouryears.
"ThiswasproofoftheideathatBMPscouldstopglioblastomabydepletingthestem-cell-likepopulationthatfeedsit,"saysHenryBrem,M.D.,chairmanoftheDepartmentofNeurosurgeryatHopkinsandacollaboratorinthestudy."Thisopensexcitingdoorstofutureresearchintotreatmentsandtherapiesforsuchadevastatingdisease."
药学论文天然药用植物蛋白质的理化性质与分离研究金锄头文库123
2018-02-03
快速回答，谢谢
天然蛋白质的组成元素 微思作业本123
小懒0无罪2018-02-03
常见的都是天然蛋白质，人工合成的蛋白质也是要遵从自然界的规律的，元素不是说添加就添加的，人工合成的蛋白质也离不开天然蛋白质的这些组成元素。蛋白质主要是由C（碳）、H（氢）、O（氧）、N（氮）组成，一般蛋白质可能还会含有P、S、Fe（铁）、Zn（锌）、Cu（铜）、B（硼）、Mn(锰)、I（碘）、Mo（钼）等 。
【求助】蛋白纯化这个蛋白真是很难搞定！ 经验共享 分析测试百科...123
hare12122009-07-09
我是研一的新手，导师昨天说要分给我一个比较难的课题，蛋白质分离纯化。我们实验室主要是做微生物生物化学与分子生物学方面的，没有专门搞蛋白分离纯化的，应该是天然蛋白的分离纯化。天然蛋白质的分离纯化比较难，主要指什么方面比较难呢？仅仅蛋白质分离纯化是不是也不够作一篇硕士论文的工作量呢，是不是也应该有后续的工作或者前期的工作呢？蛋白质分离纯化方面的课题对未来就业有何帮助？谢谢大家！十分感激！
高级生物化学问答题123
yjgao2021-07-21
【求助】10株单抗没一株能与天然蛋白反应 免疫学讨论版论坛123
luliangshun2007-01-31
小弟用E.coli表达的一蛋白(一天然毒素的N段)制备了11株单抗,但没有一株能中和天然蛋白,这可急死我了.再拖下去就不能毕业了.导师天天催我建立诊断方法呢.大家给我出出主意!
天然蛋白质中不存在的氨基酸是()。_123
爱钓鱼的小猫2014-10-15
有关信号肽的很多疑惑 分子生物 123
hfztim2007-12-10
天然蛋白疏水层析问题?_问答详情_其它天然蛋白_天然蛋白_蛋白类...123
zysshine2010-05-28
构成天然蛋白质的氨基酸有几种 123
2018-02-04
人体能产生20种
算上其他生物24种
大概是记不太清了
算上其他生物24种
大概是记不太清了
▍
品牌分类
▍
官网分类
▍
品牌问答
