
Overview:
14-3-3σorstratifinisaproteinthatisstronglyinducedbygammairrADIationandotherDNA-damagingagents(1).Theinductionof14-3-3σismediatedbyap53responsiveelement.Exogenousintroductionof14-3-3σintocyclingcellsresultsinaG2cellcyclearrest(2).Knockoutof14-3-3σincellsshowedthatthecellsareunabletomaintaincellcyclearrestafterDNAdamage.The14-3-3σ-/-cellsdieastheyentermitosis.Thisprocessisassociatedwithafailureofthe14-3-3σ-deficientcellstosequestertheproteinsthatinitiatemitosisandpreventthemfromenteringthenucleus.Thus,14-3-3σplaysanimportantroleinmaintainingtheG2checkpointincellsandpreventingmitoticdeath.
GeneAliases:
14-3-3sigma,SFN,stratifin,YWHAS
GenbankNumber:
NM_006142
References:
1.Chan,TA.etal:14-3-3-sigmaisrequiredtopreventmitoticcatastropheafterDNAdamage.Nature401:616-620,1999.2.Hermeking,H.etal:14-3-3-sigmaisap53-regulatedinhibitorofG2/Mprogression.Molec.Cell1:3-11,1997.
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
算上其他生物24种
大概是记不太清了

