
Overview:
14-3-3theta(alsoknownastyrosine3-monooxygenase/tryptophan5-monooxygenaseactivationprotein,thetapolypeptide)isamemberofthe14-3-3familyofproteinswhichmediatesignaltransductionbybindingtophosphoserine-containingproteins.ThroughinteractionwithASK1,c-junNH-terminalkinase,andp38mitogen-activatedproteinkinase(MAPK),14-3-3thetaplaysanimportantroleincontrollingapotopsis(1).Inducedexpressionof14-3-3thetaproteinhasbeenreportedinpatientswithamyotrophiclateralsclerosis.Additionally,14-3-3thetahasbeenobservedtomediatenucleo-cytoplasmicshuttlingoftheNprotein(coronavirusnucleocapsidprotein)whichcausessevereacuterespiratorysyndrome(2).
GeneAliases:
YWHAQ,1C5,HS1,14-3-3
GenbankNumber:
NM_006826
References:
1.Lau,J.M.etal:The14-3-3tauphosphoserine-bindingproteinisrequiredforcardiomyocytesurvival.MolCellBiol.2007,27(4):1455-66.2.Thesevereacuterespiratorysyndromecoronavirusnucleocapsidproteinisphosphorylatedandlocalizesinthecytoplasmby14-3-3-mediatedtranslocation.JVirol.2005Sep;79(17):11476-86.
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算上其他生物24种
大概是记不太清了

