
Overview:
14-3-3ζ(alsoknownastyrosine3-monooxygenase/tryptophan5-monooxygenaseactivationprotein,zetapolypeptide)isamemberofthe14-3-3familyofproteinswhichmediatesignaltransductionbybindingtophosphoserine-containingproteins.14-3-3ζproteinplaysakeyroleincancerBIOLOGybybeinganimportantregulatorofmajorcellularprocessessuchasproliferation,differentiation,senescenceandapoptosis(1).14-3-3ζproteinhasbeenshowntointeractwiththeIRS1protein,suggestingaroleforthisproteininregulatinginsulinsensitivitybyinterruptingtheassociationbetweentheinsulinreceptorandIRS1(2).
GeneAliases:
14-3-3zeta,YWHAZ,KCIP-1,MGC111427,MGC126532,MGC138156
GenbankNumber:
NM_003406
References:
1.Li,Z.etal:Down-regulationof14-3-3zetasuppressesanchorage-independentgrowthoflungcancercellsthroughanoikisactivation.ProcNatlAcadSciUSA.2008;105(1):162-7.2.Niemantsverdriet,M.etal:Cellularfunctionsof14-3-3zetainapoptosisandcelladhesionemphasizeitsoncogeniccharacter.Oncogene.2008;27(9):1315-9.2007
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算上其他生物24种
大概是记不太清了

